M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy

Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors. Because the M-current stabilizes membrane potential at the resting membrane potential, its suppression tra...

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Published inFrontiers in physiology Vol. 11; p. 513
Main Author Hoshi, Naoto
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 25.05.2020
Subjects
epilepsy
Kv7 channel
medium chain fatty
palmitoylation
Physiology
regulation – physiological
valproic acid
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Summary:Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors. Because the M-current stabilizes membrane potential at the resting membrane potential, its suppression transiently increase neuronal excitability. However, its physiological and pathological roles in vivo is not well understood to date. This review summarizes the molecular mechanism underlying M-current suppression, and why it remained elusive for many years. I also summarize how regulation of neuronal Kv7 channel contributes to anti-seizure action of valproic acid through inhibition of palmitoylation of a Kv7 channel binding protein, and discuss about a potential link with anti-seizure mechanisms of medium chain triglyceride ketogenic diet.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
Reviewed by: Maria Virginia Soldovieri, University of Molise, Italy; Enrique Soto, Meritorious Autonomous University of Puebla, Mexico
Edited by: Francesco Miceli, University of Naples Federico II, Italy
This article was submitted to Membrane Physiology and Membrane Biophysics, a section of the journal Frontiers in Physiology
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2020.00513