Skin compatibility of cyclodextrins and their derivatives: a comparative assessment using a corneoxenometry bioassay

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 57; no. 3; pp. 479 - 482
• Main Authors: Piel, G., Moutard, S., Uhoda, E., Pilard, F., Piérard, G.E., Perly, B., Delattre, L., Evrard, B.
• Format: Journal Article Web Resource
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2004; Elsevier Science
• Subjects: Corneoxenometry; Cyclodextrins; Cyclodextrins - chemical synthesis; Cyclodextrins - toxicity; Cyclodextrins/chemical synthesis/toxicity; Dermatologie; Dermatology; Epidermis - cytology; Epidermis - drug effects; Epidermis/cytology/drug effects; Human health sciences; Humans; Phosphatidylethanolamines - chemical synthesis; Phospholipidyl-cyclodextrins; Sciences de la santé humaine; Skin - cytology; Skin - drug effects; Skin compatibility; Skin/cytology/drug effects; Stratum corneum; Xenobiotics - toxicity; Corneoxenometry; Cyclodextrins; Skin compatibility; Stratum corneum; Phospholipidyl-cyclodextrins
• ISSN: 0939-6411; 1873-3441; 1873-3441
• DOI: 10.1016/j.ejpb.2003.12.004

Few studies have been performed to assess the risk of skin damage by cyclodextrins (CD) and they have yielded contradictory results. The present study was conducted using the corneoxenometry bioassay on human stratum corneum to compare the skin compatibility of CD currently used in pharmaceutical preparations (βCD, γCD, Rameb, Dimeb, Trimeb, HP-βCD and HP-γCD) and that of new amphiphilic CD derivatives, namely, the phospholipidyl-CD (DMPE-Dimeb and DMPE-Trimeb). All the tested CD were well tolerated by the stratum corneum at a concentration of 5%. However, inter-individual reactivity was larger for DMPE-Dimeb, suggesting a more aggressive trend for this compound. Cutaneous Index of Mildness values obtained confirm that Dimeb is able to extract some skin components and shows that DMPE-Dimeb performs similarly.