Chemical Characteristics and Immuno-stimulating Properties of Biopolymers Extracted from Acanthopanax sessiliflorus

• Published in: BMB reports Vol. 39; no. 1; pp. 84 - 90
• Main Authors: Jeong, S.C. (Daegu University, Gyeongsan, Republic of Korea), Jeong, Y.T. (Daegu University, Gyeongsan, Republic of Korea), Yang, B.K. (Daegu University, Gyeongsan, Republic of Korea), Song, C.H. (Daegu University, Gyeongsan, Republic of Korea), E-mail: chsong@daegu.ac.kr
• Format: Journal Article
• Language: English
• Published: Korea (South) 31.01.2006
• Subjects: Acanthopanax sessiliflorus; Animals; BIOPOLIMEROS; BIOPOLYMERE; BIOPOLYMERS; Biopolymers - chemistry; Biopolymers - immunology; Cell Proliferation; Cells, Cultured; Eleutherococcus - chemistry; Glycosyl linkage-composition; Immunologic Factors - chemistry; Immunologic Factors - immunology; Lymphocytes - cytology; Lymphocytes - immunology; Lymphoproliferative activity; Macrophages - cytology; Macrophages - enzymology; Macrophages - immunology; Macrophagestimulating activity; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muramidase - metabolism; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Plants, Medicinal - chemistry; Spleen - cytology
• ISSN: 1225-8687; 1976-6696; 0219-1024
• DOI: 10.5483/bmbrep.2006.39.1.084

During our search for macrophage stimulating compounds from medicinal plants, we isolated biopolymers from Acanthopanax sessiliflorus. Isolated fraction AS-5 showed maximum potential, and stimulated lysosonal enzymatic activity by 230% at 300 ㎍/ml. The nitric oxide (NO) producing ability of AS-5 100 ㎍/ml was 58 μM when treated with interferon-γ and lipopolysaccharide 20 ㎍/ml. The lymphocyte proliferating effects of isolated biopolymer fractions were also investigated. Highest lymphoproliferative activity (a 2.8-fold enhancement compared to saline treated group was exhibited by AS-3 at 200 ㎍/ml followed by AS-5 and AS-6.