Murine Leukemia Virus Infection in Immunocompetent Adult Mice
The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from...
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| Published in | Virology (New York, N.Y.) Vol. 192; no. 1; pp. 1 - 10 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
San Diego, CA
Elsevier Inc
01.01.1993
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from the tissues of these infected mice was analyzed using a polymerase chain reaction assay to detect integrated provirus. Infection in adult immunocompetent BALB.K mice results in an acute phase characterized by a high number of cells containing provirus DNA followed by a period in which provirus DNA in most tissues reaches background levels until the development of thymic lymphoma/leukemia at 4-7 months. This pattern of infection is different from what has been observed in immunosuppressed mice in which levels of virus-infected cells remain high throughout the preleukemic and leukemic phases. |
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| AbstractList | The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from the tissues of these infected mice was analyzed using a polymerase chain reaction assay to detect integrated provirus. Infection in adult immunocompetent BALB.K mice results in an acute phase characterized by a high number of cells containing provirus DNA followed by a period in which provirus DNA in most tissues reaches background levels until the development of thymic lymphoma/leukemia at 4-7 months. This pattern of infection is different from what has been observed in immunosuppressed mice in which levels of virus-infected cells remain high throughout the preleukemic and leukemic phases. |
| Author | Overmoyer, Beth Blank, Kenneth J. Clevenger, Charles V. Prystowsky, Michael B. Tumas, Kathleen |
| Author_xml | – sequence: 1 givenname: Kathleen surname: Tumas fullname: Tumas, Kathleen – sequence: 2 givenname: Beth surname: Overmoyer fullname: Overmoyer, Beth – sequence: 3 givenname: Charles V. surname: Clevenger fullname: Clevenger, Charles V. – sequence: 4 givenname: Kenneth J. surname: Blank fullname: Blank, Kenneth J. – sequence: 5 givenname: Michael B. surname: Prystowsky fullname: Prystowsky, Michael B. |
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| Keywords | Animal model Oncovirinae Rodentia Retroviridae Molecular integration Cellular immunity Provirus Infection Virus Vertebrata Experimental disease Mammalia Immunogenicity Mouse Type C oncovirus DNA Viral disease Murine leukemia virus |
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| SubjectTerms | AIDS/HIV Animals Base Sequence Biological and medical sciences DNA, Viral - genetics Experimental viral diseases and models Female Genes, env Immunity Infectious diseases Leukemia Virus, Murine - growth & development Leukemia, Experimental - immunology Leukemia, Experimental - microbiology Lymph Nodes - microbiology Male Medical sciences Mice Mice, Inbred BALB C Molecular Sequence Data murine leukemia virus Oligodeoxyribonucleotides - chemistry Polymerase Chain Reaction Viral diseases Virus Integration |
| Title | Murine Leukemia Virus Infection in Immunocompetent Adult Mice |
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