Murine Leukemia Virus Infection in Immunocompetent Adult Mice

The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from...

Full description

Saved in:
Bibliographic Details
Published inVirology (New York, N.Y.) Vol. 192; no. 1; pp. 1 - 10
Main Authors Tumas, Kathleen, Overmoyer, Beth, Clevenger, Charles V., Blank, Kenneth J., Prystowsky, Michael B.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 01.01.1993
Elsevier
Subjects
AIDS/HIV
Animals
Base Sequence
Biological and medical sciences
DNA, Viral - genetics
Experimental viral diseases and models
Female
Genes, env
Immunity
Infectious diseases
Leukemia Virus, Murine - growth & development
Leukemia, Experimental - immunology
Leukemia, Experimental - microbiology
Lymph Nodes - microbiology
Male
Medical sciences
Mice
Mice, Inbred BALB C
Molecular Sequence Data
murine leukemia virus
Oligodeoxyribonucleotides - chemistry
Polymerase Chain Reaction
Viral diseases
Virus Integration
Animal model
Oncovirinae
Rodentia
Retroviridae
Molecular integration
Cellular immunity
Provirus
Infection
Virus
Vertebrata
Experimental disease
Mammalia
Immunogenicity
Mouse
Type C oncovirus
DNA
Viral disease
Murine leukemia virus
Online AccessGet full text

Cover

More Information
Summary:The course of infection of a chronic murine leukemia virus (MuLV), E-55+, which induces thymic lymphoma/leukemia in 100% of mice infected as adults, was followed after inoculation of virus into adult mice which generate both cytotoxic T cell and neutralizing antibody responses (Blank 1976). DNA from the tissues of these infected mice was analyzed using a polymerase chain reaction assay to detect integrated provirus. Infection in adult immunocompetent BALB.K mice results in an acute phase characterized by a high number of cells containing provirus DNA followed by a period in which provirus DNA in most tissues reaches background levels until the development of thymic lymphoma/leukemia at 4-7 months. This pattern of infection is different from what has been observed in immunosuppressed mice in which levels of virus-infected cells remain high throughout the preleukemic and leukemic phases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1993.1001