Critical Evaluation of Gene Expression Changes in Human Tissues in Response to Supplementation with Dietary Bioactive Compounds: Moving Towards Better-Quality Studies

• Published in: Nutrients Vol. 10; no. 7; p. 807
• Main Authors: Pokimica, Biljana, García-Conesa, María-Teresa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.06.2018; MDPI
• Subjects: bioactive compounds; Biological Availability; Cell Line; clinical trials; dietary nutrient sources; Dietary Supplements; experimental design; Gene Expression; Gene Expression Profiling; Gene Targeting; genes; guidelines; Humans; mechanism of action; Phytochemicals - administration & dosage; Phytochemicals - pharmacokinetics; quantitative polymerase chain reaction; Randomized Controlled Trials as Topic; reverse transcriptase polymerase chain reaction; Review; Tissue Distribution; tissues; transcription (genetics); mRNA levels; plant food bioactives; RT-qPCR; human tissues; interindividual variability; health effects

Pre-clinical cell and animal nutrigenomic studies have long suggested the modulation of the transcription of multiple gene targets in cells and tissues as a potential molecular mechanism of action underlying the beneficial effects attributed to plant-derived bioactive compounds. To try to demonstrat...