Acute and Chronic Effects of Exercise on Continuous Glucose Monitoring Outcomes in Type 2 Diabetes: A Meta-Analysis
Objective: To examine the acute and chronic effects of structured exercise on glucose outcomes assessed by continuous glucose monitors in adults with type 2 diabetes. Methods: PubMed, Medline, EMBASE were searched up to January 2020 to identify studies prescribing structured exercise interventions w...
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Published in | Frontiers in endocrinology (Lausanne) Vol. 11 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
04.08.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Objective:
To examine the acute and chronic effects of structured exercise on glucose outcomes assessed by continuous glucose monitors in adults with type 2 diabetes.
Methods:
PubMed, Medline, EMBASE were searched up to January 2020 to identify studies prescribing structured exercise interventions with continuous glucose monitoring outcomes in adults with type 2 diabetes. Randomized controlled trials, crossover trials, and studies with pre- and post-designs were eligible. Short-term studies were defined as having exercise interventions lasting ≤2 weeks. Longer-term studies were defined as >2 weeks.
Results:
A total of 28 studies were included. Of these, 23 studies were short-term exercise interventions. For all short-term studies, the same participants completed a control condition as well as at least one exercise condition. Compared to the control condition, exercise decreased the primary outcome of mean 24-h glucose concentrations in short-term studies (−0.5 mmol/L, [−0.7, −0.3];
p
< 0.001). In longer-term studies, mean 24-h glucose was not significantly reduced compared to control (−0.9 mmol/L [−2.2, 0.3],
p
= 0.14) but was reduced compared to pre-exercise values (−0.5 mmol/L, [−0.7 to −0.2]
p
< 0.001). The amount of time spent in hyperglycemia and indices of glycemic variability, but not fasting glucose, also improved following short-term exercise. Among the shorter-term studies, subgroup, and regression analyses suggested that the timing of exercise and sex of participants explained some of the heterogeneity among trials.
Conclusion:
Both acute and chronic exercise can improve 24-h glucose profiles in adults with type 2 diabetes. The timing of exercise and sex of participants are among the factors that may explain part of the heterogeneity in acute glycemic improvements following exercise. |
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Bibliography: | This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology Reviewed by: Richard M. Bracken, Swansea University, United Kingdom; Steven K. Malin, University of Virginia, United States Edited by: John P. Thyfault, University of Kansas Medical Center, United States |
ISSN: | 1664-2392 1664-2392 |
DOI: | 10.3389/fendo.2020.00495 |