Changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal-directed hemodynamic optimization at admission to ICU and the relation to outcome
Objective To evaluate the changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal‐directed hemodynamic optimization in the ICU and their relation to outcome. Design Prospective observational study. Setting ICU of a veterinary university medical center. Anim...
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Published in | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2000) Vol. 22; no. 4; pp. 409 - 418 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.08.2012
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
To evaluate the changes in tissue perfusion parameters in dogs with severe sepsis/septic shock in response to goal‐directed hemodynamic optimization in the ICU and their relation to outcome.
Design
Prospective observational study.
Setting
ICU of a veterinary university medical center.
Animals
Thirty dogs with severe sepsis or septic shock caused by pyometra who underwent surgery and were admitted to the ICU.
Measurements and Main Results
Severe sepsis was defined as the presence of sepsis and sepsis‐induced dysfunction of one or more organs. Septic shock was defined as the presence of severe sepsis plus hypotension not reversed with fluid resuscitation. After the presumptive diagnosis of sepsis secondary to pyometra, blood samples were collected and clinical findings were recorded. Volume resuscitation with 0.9% saline solution and antimicrobial therapy were initiated. Following abdominal ultrasonography and confirmation of increased uterine volume, dogs underwent corrective surgery. After surgery, the animals were admitted to the ICU, where resuscitation was guided by the clinical parameters, central venous oxygen saturation (ScvO2), lactate, and base deficit. Between survivors and nonsurvivors it was observed that the ScvO2, lactate, and base deficit on ICU admission were each related independently to death (P = 0.001, P = 0.030, and P < 0.001, respectively). ScvO2 and base deficit were found to be the best discriminators between survivors and nonsurvivors as assessed via receiver operator characteristic curve analysis.
Conclusion
Our study suggests that ScvO2 and base deficit are useful in predicting the prognosis of dogs with severe sepsis and septic shock; animals with a higher ScvO2 and lower base deficit at admission to the ICU have a lower probability of death. |
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Bibliography: | istex:71131C2521B8D631A0558D55B8F858ABD62EEA2B ArticleID:VEC769 ark:/67375/WNG-7CDQTZF2-F Presented in part at the 16th International Veterinary Emergency and Critical Care Symposium, San Antonio, TX, September 2010. Authors declare no conflict of interests. Financial support: FAPESP—Foundation of Support to Research of the State of São Paulo. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1479-3261 1476-4431 |
DOI: | 10.1111/j.1476-4431.2012.00769.x |