In Response to Precision Medicine: Current Subcellular Targeting Strategies for Cancer Therapy

• Published in: Advanced materials (Weinheim) Vol. 35; no. 21; pp. e2209529 - n/a
• Main Authors: Li, Zheng, Zou, Jianhua, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2023
• Subjects: cancer therapy; Cell Nucleus; Drug Delivery Systems; Endoplasmic reticulum; Humans; Materials science; Micelles; Mitochondria; molecules; Nanomaterials; Nanoparticles; Neoplasms - drug therapy; Neoplasms - pathology; Organelles; Precision Medicine; Radiation therapy; subcellular organelle targeting; cancer therapy; precision medicine; nanomaterials; subcellular organelle targeting; molecules
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.202209529

Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn increasing attention, bringing great opportunities for clinical application. Here, two targeting strategies for four main subcellular organelles (mitochondria, lysosome, endoplasmic reticulum, and nucleus), including molecule‐ and nanomaterial (inorganic nanoparticles, micelles, organic polymers, and others)‐based targeted delivery or therapeutic strategies, are summarized. Phototherapy, chemotherapy, radiotherapy, immunotherapy, and “all‐in‐one” combination therapy are among the strategies covered in detail. Such materials are constructed based on the specific properties and relevant mechanisms of organelles, enabling the elimination of tumors by inducing dysfunction in the corresponding organelles or destroying specific structures. The challenges faced by organelle‐targeting cancer therapies are also summarized. Looking forward, a paradigm for organelle‐targeting therapy with enhanced therapeutic efficacy compared to current clinical approaches is envisioned. Subcellular targeting is very promising for cancer treatment. The recent progress of subcellular targeting strategies is summarized, concentrating on direct and indirect targeting of four main organelles (mitochondria, lysosome, endoplasm reticulum, and nucleus) on the basis of various formulations. Finally, prospects and challenges of subcellular targeting are also discussed.