Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development

Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimula...

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Published inJournal of leukocyte biology Vol. 55; no. 5; pp. 658 - 661
Main Authors Armstrong, J. W., Simske, S. J., Beharka, A. A., Balch, S., Luttges, M. W., Chapes, S. K., Spooner, B. S.
Format Journal Article
LanguageEnglish
Published Legacy CDMS Society for Leukocyte Biology 01.05.1994
Federation of American Societies for Experimental Biology
Subjects
Animals
Antigens
Biological and medical sciences
Bone Marrow - physiology
Bone Marrow Cells
Cell Differentiation - physiology
Cells, Cultured
colony‐stimulating factor 1
Fundamental and applied biological sciences. Psychology
Fundamental immunology
hematopoiesis
Histocompatibility antigens (hla, h-2 and other systems)
Histocompatibility Antigens Class I - analysis
Histocompatibility Antigens Class I - physiology
Histocompatibility Antigens Class II - analysis
Histocompatibility Antigens Class II - physiology
Life Sciences (General)
macrophages
Macrophages - cytology
Macrophages - physiology
MHC
Mice
Mice, Inbred C3H
Molecular immunology
Space life sciences
T-Lymphocytes - cytology
T-Lymphocytes - physiology
Non-Nasa Center
Nasa Discipline Cell Biology
Biological properties
Vertebrata
Mammalia
Cell population
Mouse
Major histocompatibility system
Rodentia
Class II histocompatibility antigen
Development
Bone marrow
Class I histocompatibility antigen
Macrophage
NASA Discipline Cell Biology
Non-NASA Center
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Summary:Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.
Bibliography:CDMS
Legacy CDMS
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ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.55.5.658