Dioxetane Derivative Containing Carboxy Group as a Chemiluminophore‐Introducing Reagent

Some types of dioxetanes are called chemiluminophores because they produce luminescence light without the use of enzymes. Here, we designed and synthesized a novel carboxy group‐containing chemiluminophore derivative, which enabled the simple introduction of such a chemiluminophore to the molecule o...

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Published inChembiochem : a European journal of chemical biology Vol. 23; no. 24; pp. e202200556 - n/a
Main Authors Nohara, Yukie, Masuda, Shun, Kaneda‐Nakashima, Kazuko, Shirakami, Yoshifumi, Matsumoto, Masakatsu, Yoshiya, Taku
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 16.12.2022
Wiley Subscription Services, Inc
Subjects
Biochemistry & Molecular Biology
chemiluminophore
Chemistry, Medicinal
CIEEL
dioxetane
glucose probes
Heterocyclic Compounds - chemistry
Heterocyclic Compounds, 1-Ring
Indicators and Reagents
in vivo imaging
Life Sciences & Biomedicine
Luminescence
Luminescent Measurements
Pharmacology & Pharmacy
Reagents
Science & Technology
in vivo imaging
2-NBDG
ACID
CIEEL
glucose probes
CHEMILUMINESCENCE
chemiluminophore
MODEL
dioxetane
in vivo imaging
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Summary:Some types of dioxetanes are called chemiluminophores because they produce luminescence light without the use of enzymes. Here, we designed and synthesized a novel carboxy group‐containing chemiluminophore derivative, which enabled the simple introduction of such a chemiluminophore to the molecule of interest. Furthermore, we demonstrate that the in vivo imaging system (IVIS imaging system) can recognize tagged chemicals, indicating that such a chemiluminophore could be employed as a tracer molecule for biological studies. A novel carboxy group‐containing chemiluminophore derivative, which enabled the simple introduction of a chemiluminophore to the molecule of interest, was developed. This chemiluminophore cast luminescence light without enzymes, such as luciferase. Chemiluminophore‐containing probes thus obtained could be visualized by in vivo imaging system.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202200556