Leptin Is a Link between Adipose Tissue and Inflammation

:  Leptin is a hormone of the pluripotent white adipose tissue and confers a multitude of regulatory functions within the organism. It controls the energy storage, lipoprotein metabolism, acute phase reactants, sex hormones and glucocorticoid metabolism, and immune function. In this review, we descr...

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Bibliographic Details
Published inAnnals of the New York Academy of Sciences Vol. 1069; no. 1; pp. 454 - 462
Main Authors HÄRLE, PETER, STRAUB, RAINER H.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.06.2006
Subjects
Adipose Tissue - immunology
Adipose Tissue - metabolism
Adipose Tissue - secretion
Animals
Autoimmunity - immunology
Humans
immune system
Inflammation - immunology
Inflammation - metabolism
leptin
Leptin - immunology
Leptin - metabolism
Leptin - secretion
neuroendocrine system
Steroids - biosynthesis
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Summary::  Leptin is a hormone of the pluripotent white adipose tissue and confers a multitude of regulatory functions within the organism. It controls the energy storage, lipoprotein metabolism, acute phase reactants, sex hormones and glucocorticoid metabolism, and immune function. In this review, we describe these multiple functions of leptin, the regulation of leptin expression, and how leptin can modulate the immune system via direct and indirect mechanisms. We show how leptin can be a link between the adipose tissue and inflammation.
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ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1351.044