Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae

• Published in: FEMS yeast research Vol. 14; no. 1; pp. 60 - 72
• Main Authors: Ayer, Anita, Gourlay, Campbell W., Dawes, Ian W.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2014; Oxford University Press
• Subjects: Aging; Homeostasis; Models, Biological; Oxidation-Reduction; Oxidative stress; Reactive oxygen species; Reactive Oxygen Species - metabolism; redox homeostasis; Redox properties; replicative ageing; Saccharomyces cerevisiae; Saccharomyces cerevisiae - growth & development; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae - physiology; Yeast; replicative ageing; redox homeostasis; reactive oxygen species
• ISSN: 1567-1356; 1567-1364
• DOI: 10.1111/1567-1364.12114

Abstract Ageing cells undergo changes in redox homeostasis and acquire high levels of reactive oxygen species (ROS). Because accumulation of ROS involves a change in redox state of cells, functions that are involved in setting redox and maintaining redox homeostasis are very relevant to an understanding of the possible roles of redox homeostasis and ROS in ageing. This review discusses these aspects of ROS in relation to replicative ageing in the model organism Saccharomyces cerevisiae, with reference to ROS generated in cells; cellular responses to oxidative stress; and how cells maintain redox homeostasis in different cellular compartments. It also considers when ROS generation begins as cells age, which ROS species are relevant to ageing and which cellular compartments and processes may contribute ROS to the ageing process. The discussion also covers the heterogeneity of cells with respect to ROS accumulation at particular cell ages, and the possibility of testing the oxidative theory of ageing in yeast cells. This review discusses the changes in reactive oxygen species and redox state in different cellular compartments that occur as cells undergo ageing. This review discusses the changes in reactive oxygen species and redox state in different cellular compartments that occur as cells undergo ageing.