Innate immunity and graft rejection

Although innate immunity evolved to combat pathogens, increasing awareness of a pivotal role in driving and shaping adaptive immunity has prompted this review on the role of innate immunity in graft rejection. We present evidence that grafts, especially xenografts, elicit innate responses, required...

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Bibliographic Details
Published inImmunological reviews Vol. 173; no. 1; pp. 141 - 147
Main Authors Fox, Annette, Harrison, Leonard C.
Format Journal Article
LanguageEnglish
Published Copenhagen Munksgaard International Publishers 01.02.2000
Subjects
Adoptive Transfer
Animals
Cell Movement
Graft Rejection - immunology
Immunity, Innate
Inflammation Mediators
innate immunity
Killer Cells, Natural
Mice
Swine
T-Lymphocytes - immunology
Transplantation, Heterologous
Transplantation, Homologous
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Summary:Although innate immunity evolved to combat pathogens, increasing awareness of a pivotal role in driving and shaping adaptive immunity has prompted this review on the role of innate immunity in graft rejection. We present evidence that grafts, especially xenografts, elicit innate responses, required for adaptive immunity. Particular attention is paid to studies by ourselves and others demonstrating the important role of innate immunity in T‐cell trafficking. The mechanisms by which grafts elicit innate immunity are a fertile subject for further investigation and an important target for therapeutic intervention.
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ISSN:0105-2896
1600-065X
DOI:10.1034/j.1600-065X.2000.917313.x