Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

• Published in: Advanced materials (Weinheim) Vol. 33; no. 48; pp. e2104223 - n/a
• Main Authors: Zhou, Yaofeng, Fan, Siyu, Feng, Lili, Huang, Xiaolin, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.12.2021
• Subjects: Cancer; chemodynamic therapy; Combined Modality Therapy; Efficiency; Fenton chemistry; Free radicals; Genetic Therapy; Humans; Hydrogen Peroxide - chemistry; Hydroxyl Radical - chemistry; Hydroxyl Radical - metabolism; Hydroxyl Radical - therapeutic use; Immunotherapy; Iron - chemistry; Materials science; multimodal synergistic therapies; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Nanoparticles - toxicity; Neoplasms - drug therapy; Neoplasms - therapy; Reinforcement; reinforcement strategies; Therapy; Tumors; Ultraviolet Rays; multimodal synergistic therapies; reinforcement strategies; Fenton chemistry; chemodynamic therapy

Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective tumor treatment. However, the limited intratumoral Fenton reaction efficiency restricts the therapeutic efficacy of CDT. Rece...