All‐in‐One Nanomedicine: Multifunctional Single‐Component Nanoparticles for Cancer Theranostics

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 52; pp. e2103072 - n/a
• Main Authors: Cai, Yu, Chen, Xiaoyi, Si, Jingxing, Mou, Xiaozhou, Dong, Xiaochen
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.12.2021
• Subjects: Biocompatibility; Biomedical materials; Cancer; Humans; Medical imaging; multifunction; Nanomedicine; Nanoparticles; Nanotechnology; Neoplasms - diagnosis; Neoplasms - therapy; Precision Medicine; Reproducibility of Results; Side effects; single‐component nanoparticles; Theranostic Nanomedicine; theranostics; nanomedicine; theranostics; cancer; single-component nanoparticles; multifunction
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.202103072

The development of cancer diagnostic imaging and treatment is a major concern worldwide. By integrating imaging and therapy into one theranostic nanoplatform for simultaneously detecting tumors, evaluating the targeting ability and timely monitoring therapeutic responses provide more opportunities for precision medicine. Among various theranostic nanosystems, a series of single‐component nanoparticles (NPs) have been developed for “all‐in‐one” theranostics, which presents the unique properties of facile preparation, simple composition, defined structure, high reproducibility, and excellent biocompatibility. Specifically, utilizing single‐component NPs for both diagnostics and therapeutics can reduce the possible numerous untoward side effects and risks to the living body. In this review, the recent progress of multifunctional single‐component NPs in the applications of cancer theranostics is systematically summarized. Notably, the structure design, categories of NPs, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed. The development of cancer diagnostic imaging and treatment is a major concern worldwide. This review systematically summarizes the recent progress of multifunctional single‐component nanoparticles in the applications of cancer theranostics. The structure design, categories of nanoparticles, targeted strategies, biomedical applications, potential barriers, challenges, and prospects for the future clinical practice of this rapidly growing field are discussed.