Acute interstitial nephritis observed with three different triggering agents

A 70‐year‐old female patient developed acute interstitial nephritis (AIN) after treatment with non‐steroidal anti‐inflammatory drugs (NSAIDs), proton pump inhibitors (PPI), and Bromhexine. Renal biopsy confirmed the diagnosis, and the patient was treated with oral prednisone. Careful attention to ti...

Full description

Saved in:
Bibliographic Details
Published inClinical case reports Vol. 10; no. 3; pp. e05432 - n/a
Main Authors Nobakht, Niloofar, Hanna, Ramy M., Kamgar, Mohammad, Sinclair, John, Simon, Lewis, Emami, Sina, Sisk, Anthony, Rastogi, Anjay
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.03.2022
John Wiley and Sons Inc
Wiley
Subjects
AIN
AKI
ATN
Biopsy
Blood
bromhexine
Case Report
Case Reports
Creatinine
Disease prevention
Enzymes
Fever
Food contamination & poisoning
Hypertension
Hyponatremia
Inflammation
Kidneys
Microscopy
Nephrology
Nonsteroidal anti-inflammatory drugs
NSAIDS
Patients
PPI
Steroids
Urinalysis
Urine
PPI
ATN
bromhexine
AIN
NSAIDS
AKI
Online AccessGet full text

Cover

More Information
Summary:A 70‐year‐old female patient developed acute interstitial nephritis (AIN) after treatment with non‐steroidal anti‐inflammatory drugs (NSAIDs), proton pump inhibitors (PPI), and Bromhexine. Renal biopsy confirmed the diagnosis, and the patient was treated with oral prednisone. Careful attention to timing of acute kidney injury (AKI) is crucial to diagnosing AIN. Several drugs can cause allergic interstitial nephritis (AIN) including over the counter agents. Bromhexine an over the counter cough remedies can be associated with AIN. The timing of treatment initiation with steroid is critical to decrease risk of fibrosis and future chronic kidney disease and loss of GFR.
Bibliography:Funding information
This work was not sponsored
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Report-1
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.5432