Porphyrin metabolism in hepatitis C infection

Hepatitis C virus has been implicated as a major precipitating factor in porphyria cutanea tarda (PCT). To determine whether hepatitis C infection alone is sufficient to induce PCT, we screened two groups of patients with hepatitis C infection. The first group comprised women who had become HCV posi...

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Bibliographic Details
Published inPhotodermatology, photoimmunology & photomedicine Vol. 12; no. 1; p. 31
Main Authors O'Reilly, F M, Darby, C, Fogarty, J, O'Moore, R, Courtney, M G, O'Connor, J, Kay, E W, Leader, M, Fielding, J F, Murphy, G M
Format Journal Article
LanguageEnglish
Published England 01.02.1996
Subjects
Adolescent
Adult
Aged
Female
Hepatitis C - complications
Hepatitis C - metabolism
Humans
Immunization
Immunoglobulin D - immunology
Male
Middle Aged
Porphyria Cutanea Tarda - virology
Porphyrins - metabolism
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Summary:Hepatitis C virus has been implicated as a major precipitating factor in porphyria cutanea tarda (PCT). To determine whether hepatitis C infection alone is sufficient to induce PCT, we screened two groups of patients with hepatitis C infection. The first group comprised women who had become HCV positive secondary to immunization with anti-D immunoglobulin (group 1). Group 2 included males and females who were HCV positive but HIV negative secondary to intravenous drug abuse. Though both groups had very abnormal liver function tests, we found no significant abnormalities in porphyrin metabolism in these groups of patients. Therefore, in this study population, we conclude that HCV infection alone is insufficient to cause porphyrin metabolic derangement.
ISSN:0905-4383
DOI:10.1111/j.1600-0781.1996.tb00241.x