Modulation of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Expression in Explant-Cultured Guinea Pig Cardiac Neurons

:  Pituitary adenylate cyclase‐activating polypeptide (PACAP) expression was quantified in explant‐cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP‐immunoreactive neurons and pro‐PACAP transcript levels increased significantly. Treatment with neurturin or...

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Published inAnnals of the New York Academy of Sciences Vol. 1070; no. 1; pp. 298 - 302
Main Authors GIRARD, BEATRICE M., YOUNG, BETH A., BUTTOLPH, THOMAS R., WHITE, SHERYL L., PARSONS, RODNEY L.
Format Journal Article
LanguageEnglish
Published Malden, USA Blackwell Publishing Inc 01.07.2006
Subjects
Animals
cardiac neurons
Cell Proliferation
Explants
Female
Gene Expression Regulation
Guinea Pigs
Male
Myocardium - cytology
Myocardium - metabolism
Neurons - cytology
Neurons - metabolism
pituitary adenylate cyclase-activating polypeptide
Pituitary Adenylate Cyclase-Activating Polypeptide - genetics
Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism
trophic factors
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Summary::  Pituitary adenylate cyclase‐activating polypeptide (PACAP) expression was quantified in explant‐cultured guinea pig cardiac ganglia neurons. In explant culture, both the percentage of PACAP‐immunoreactive neurons and pro‐PACAP transcript levels increased significantly. Treatment with neurturin or glial‐derived neurotrophic factor significantly suppressed the percentage of PACAP‐IR neurons, but not pro‐PACAP transcript levels.
Bibliography:ark:/67375/WNG-SNQ7ZP25-9
ArticleID:NYAS30
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
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ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1317.030