Neuronal loss drives differentially expressed protein‐pathways in the PSP globus pallidus

[...]the mitochondrial signal observed in model I is attenuated when accounting for cell-type composition bias. [...]following adjustment for cell-type composition, we find no significantly differentially expressed proteins between PSP and HC. [...]while we consider the study by Jang et al. to be an...

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Published inClinical and translational medicine Vol. 13; no. 7; pp. e1280 - n/a
Main Authors Dick, Fiona, Johanson, Gard S., Tzoulis, Charalampos
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.07.2023
John Wiley and Sons Inc
Wiley
Subjects
Brain
Clinical medicine
Globus Pallidus
Humans
Mass spectrometry
mitochondria
Neurodegeneration
progressive supranuclear palsy
Protein expression
Proteins
Proteomics
ribosomes
Scientific imaging
Supranuclear Palsy, Progressive
tau Proteins
neurodegeneration
ribosomes
proteomics
mitochondria
progressive supranuclear palsy
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Summary:[...]the mitochondrial signal observed in model I is attenuated when accounting for cell-type composition bias. [...]following adjustment for cell-type composition, we find no significantly differentially expressed proteins between PSP and HC. [...]while we consider the study by Jang et al. to be an important contribution of novel data to the field, we advocate caution when interpreting the results.
Bibliography:Fiona Dick and Gard S. Johanson contributed equally to this work.
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ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.1280