Aging: a New Perspective on an Old Issue

Abstract The world is undergoing a profound demographic change with a rapid increase in the prevalence of aged individuals. The finitude of life, the burden of senescence and the search for strategies to prolong human life span have troubled humanity since ancient times. However, only in the past fe...

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Published inAnais da Academia Brasileira de Ciências Vol. 92; no. 2; p. e20200437
Main Author MORI, MARCELO A.
Format Journal Article
LanguageEnglish
Published Academia Brasileira de Ciências 01.01.2020
Subjects
adipose tissue
aging
diabetes
DICER
longevity
miRNAs
MULTIDISCIPLINARY SCIENCES
adipose tissue
longevity
aging
DICER
miRNAs
diabetes
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Summary:Abstract The world is undergoing a profound demographic change with a rapid increase in the prevalence of aged individuals. The finitude of life, the burden of senescence and the search for strategies to prolong human life span have troubled humanity since ancient times. However, only in the past few decades we started to understand how organisms age and how life span can be manipulated. Here I give an historical perspective of the aging field and conclude with the notion that aging is controlled by signals from the adipose tissue which are tightly controlled by small non-coding RNAs such as miRNAs.
Bibliography:ObjectType-Article-1
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ISSN:0001-3765
1678-2690
1678-2690
DOI:10.1590/0001-3765202020200437