Estrogen signaling in growth plate cartilage
It is well known that sex steroids, in particular estrogens, play an important role in longitudinal bone growth during puberty. High doses of estrogen therapy can reduce the final height of an individual, but such treatment is also associated with severe side effects. At the same time, attenuation o...
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Published in | Endocrine development Vol. 21; p. 42 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Switzerland
01.01.2011
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Abstract | It is well known that sex steroids, in particular estrogens, play an important role in longitudinal bone growth during puberty. High doses of estrogen therapy can reduce the final height of an individual, but such treatment is also associated with severe side effects. At the same time, attenuation of estrogen production by aromatase inhibitors increases adult final height, inhibiting bone turnover, which influences bone architecture and may increase the risk for vertebrae fractures. SERMs, which display either estrogenic and/or antiestrogenic effects, bind to ERs with different affinities and subsequently recruit co-modulators of transcription in a tissue-specific manner. |
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AbstractList | It is well known that sex steroids, in particular estrogens, play an important role in longitudinal bone growth during puberty. High doses of estrogen therapy can reduce the final height of an individual, but such treatment is also associated with severe side effects. At the same time, attenuation of estrogen production by aromatase inhibitors increases adult final height, inhibiting bone turnover, which influences bone architecture and may increase the risk for vertebrae fractures. SERMs, which display either estrogenic and/or antiestrogenic effects, bind to ERs with different affinities and subsequently recruit co-modulators of transcription in a tissue-specific manner. |
Author | Karimian, Elham Sävendahl, Lars |
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CitedBy_id | crossref_primary_10_1515_jpem_2022_0536 crossref_primary_10_1007_s00280_015_2838_0 crossref_primary_10_1515_jpem_2018_0266 crossref_primary_10_6061_clinics_2014_12_10 crossref_primary_10_1016_j_aquatox_2014_03_028 crossref_primary_10_1007_s00167_012_2280_3 crossref_primary_10_1016_j_jsbmb_2017_06_008 crossref_primary_10_1007_s00018_013_1317_1 crossref_primary_10_1007_s00198_023_06760_4 crossref_primary_10_59324_ejtas_2024_2_3__39 |
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SubjectTerms | Adult Animals Bone Development - drug effects Bone Development - genetics Bone Development - physiology Cartilage - drug effects Cartilage - growth & development Cartilage - metabolism Estrogens - metabolism Estrogens - pharmacology Estrogens - physiology Growth Plate - drug effects Growth Plate - growth & development Growth Plate - metabolism Humans Models, Biological Signal Transduction - drug effects Signal Transduction - genetics Transcription, Genetic - drug effects Transcription, Genetic - genetics |
Title | Estrogen signaling in growth plate cartilage |
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