Estrogen signaling in growth plate cartilage

It is well known that sex steroids, in particular estrogens, play an important role in longitudinal bone growth during puberty. High doses of estrogen therapy can reduce the final height of an individual, but such treatment is also associated with severe side effects. At the same time, attenuation o...

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Bibliographic Details
Published inEndocrine development Vol. 21; p. 42
Main Authors Karimian, Elham, Sävendahl, Lars
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.2011
Subjects
Adult
Animals
Bone Development - drug effects
Bone Development - genetics
Bone Development - physiology
Cartilage - drug effects
Cartilage - growth & development
Cartilage - metabolism
Estrogens - metabolism
Estrogens - pharmacology
Estrogens - physiology
Growth Plate - drug effects
Growth Plate - growth & development
Growth Plate - metabolism
Humans
Models, Biological
Signal Transduction - drug effects
Signal Transduction - genetics
Transcription, Genetic - drug effects
Transcription, Genetic - genetics
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Summary:It is well known that sex steroids, in particular estrogens, play an important role in longitudinal bone growth during puberty. High doses of estrogen therapy can reduce the final height of an individual, but such treatment is also associated with severe side effects. At the same time, attenuation of estrogen production by aromatase inhibitors increases adult final height, inhibiting bone turnover, which influences bone architecture and may increase the risk for vertebrae fractures. SERMs, which display either estrogenic and/or antiestrogenic effects, bind to ERs with different affinities and subsequently recruit co-modulators of transcription in a tissue-specific manner.
ISSN:1662-2979
DOI:10.1159/000328126