Angiographic Evaluation of Vascular Damage in Rat Liver After Administration of Epirubicin or Miriplatin

• Published in: Anticancer research Vol. 38; no. 1; pp. 247 - 251
• Main Authors: Kishimoto, Shuichi, Aoki, Hiroki, Suzuki, Ryosuke, Inoue, Mai, Fukushima, Shoji
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.01.2018
• Subjects: Angiography; Animals; Blood flow; Blood vessels; Computed tomography; Damage assessment; Epirubicin; Hepatocellular carcinoma; Liver; Liver cancer; Medical imaging; Oils & fats; Portal vein; Rodents; Soybean oil; Soybeans; Vegetable oils; epirubicin; vascular damage; Miriplatin; liver; lipiodol
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.12214

Maintaining the function of blood vessels is important for the control of hepatocellular carcinoma (HCC) during treatment with repeated transcatheter arterial chemoembolization (TACE). This study was designed to compare the vascular damage caused by miriplatin (MPT), which has been commonly used for TACE, with the damage caused by epirubicin (EPI). We used the portal vein of healthy rats for the administration of the drug (MPT or EPI) and/or soybean oil as vehicle. After 2 days, angiography was performed by X-ray computer tomography. The influence of soybean oil on blood vessel function was volume-dependent. EPI showed dose-dependent effects on angiography, and 0.5 mg EPI led to severe (grade 4) blood flow disturbance in all animals. The effect of 1 mg MPT on blood vessels was mild (grade 1) in all animals and not different from that of soybean oil alone. Less vascular damage is caused by MPT than by EPI, suggesting that MPT is a useful drug for TACE in HCC.