Molecular Mechanisms of Cadmium-Induced Nonspecific Mitochondrial Permeability
In mitochondria obtained from the rat liver, we confirmed the ability of Cd 2+ to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochon...
Saved in:
| Published in | Neurophysiology (New York) Vol. 43; no. 6; pp. 494 - 497 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Boston
Springer US
01.03.2012
Springer Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | In mitochondria obtained from the rat liver, we confirmed the ability of Cd
2+
to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of Cd
2+
with just the ADP/ATP antiporter. |
|---|---|
| AbstractList | In mitochondria obtained from the rat liver, we confirmed the ability of Cd
2+
to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of Cd
2+
with just the ADP/ATP antiporter. In mitochondria obtained from the rat liver, we confirmed the ability of [Cd.sup.2+] to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of [Cd.sup.2+] with just the ADP/ATP antiporter. In mitochondria obtained from the rat liver, we confirmed the ability of Cd^sup 2+^ to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of Cd^sup 2+^ with just the ADP/ATP antiporter.[PUBLICATION ABSTRACT] In mitochondria obtained from the rat liver, we confirmed the ability of Cd super(2+) to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of Cd super(2+) with just the ADP/ATP antiporter. In mitochondria obtained from the rat liver, we confirmed the ability of [Cd.sup.2+] to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of [Cd.sup.2+] with just the ADP/ATP antiporter. Keywords: mitochondria, cadmium-induced nonspecific mitochondrial permeability, porin, ADP/ATP antiporter, cyclophilin D. |
| Audience | Academic |
| Author | Fedirko, N. V. Kravenskaya, E. V. |
| Author_xml | – sequence: 1 givenname: E. V. surname: Kravenskaya fullname: Kravenskaya, E. V. email: k.evgeniya.v@gmail.com organization: Ivan Franko National University – sequence: 2 givenname: N. V. surname: Fedirko fullname: Fedirko, N. V. organization: Ivan Franko National University |
| BookMark | eNp1kcFq3DAQhkVJoZu0D9Cb6aX04HQk27J0DEvTLmTTkjRnoZVGGwVb2ko2NG9fLQ6EBIoOA5rvG4b5T8lJiAEJ-UjhnAL0XzOlwFkNlNWSdW3dviEr2vVNLUv3hKwAJNRM9v07cprzAwBwIbsVud7GAc086FRt0dzr4POYq-iqtbajn8d6E-xs0FbXMeQDGu-8qbZ-iuY-Bpu8HqpfmEbUOz_46fE9eev0kPHDUz0jd5fffq9_1Fc_v2_WF1e1aRsx1Y5y2VgLyK00negAG75j0FJpQVgqHXW8bWjPd4Y7A2ipkUzizukeBNi-OSOfl7mHFP_MmCc1-mxwGHTAOGclGRdCNoIX8tMr8iHOKZTlCkR7JtqGFeh8gfZ6QOWDi1PSpjyLozfl0s6X_4umE305J7RF-PJCKMyEf6e9nnNWm9ublyxdWJNizgmdOiQ_6vSoKKhjeGoJT5Xw1DE8dXTY4uTChj2m563_L_0DVMmcjA |
| Cites_doi | 10.1023/A:1018457305212 10.1074/jbc.M212661200 10.1007/s11062-009-9045-8 10.1152/ajprenal.00224.2004 10.1016/S0162-0134(03)00314-3 10.1081/CLT-100100950 10.1152/ajpcell.00049.2005 10.1021/bi00892a002 10.1016/S0300-483X(03)00327-5 10.1016/S0003-9861(02)00400-9 10.1016/S1357-2725(00)00041-8 10.1007/s10495-007-0723-y 10.1111/j.1432-1033.1984.tb08513.x 10.1023/A:1010607307099 10.1007/978-1-4615-0667-6_38 10.1002/jcb.10761 10.1016/0006-291X(74)91016-X 10.1007/BF00762419 10.1016/0304-4157(95)00003-A 10.1016/S0021-9258(18)56449-8 |
| ContentType | Journal Article |
| Copyright | Springer Science+Business Media, Inc. 2012 COPYRIGHT 2012 Springer |
| Copyright_xml | – notice: Springer Science+Business Media, Inc. 2012 – notice: COPYRIGHT 2012 Springer |
| DBID | AAYXX CITATION ISR 3V. 7RV 7TK 7X7 7XB 88A 88G 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 LK8 M0S M2M M7P NAPCQ PQEST PQQKQ PQUKI PRINS PSYQQ Q9U |
| DOI | 10.1007/s11062-012-9254-4 |
| DatabaseName | CrossRef Gale In Context: Science ProQuest Central (Corporate) Nursing & Allied Health Database (ProQuest) Neurosciences Abstracts Health & Medical Complete (ProQuest Database) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Biological Sciences Health & Medical Collection (Alumni Edition) Psychology Database (ProQuest) Biological Science Database Nursing & Allied Health Premium ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic |
| DatabaseTitle | CrossRef ProQuest One Psychology ProQuest Central Student ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest Central (Alumni) |
| DatabaseTitleList | ProQuest One Psychology Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1573-9007 |
| EndPage | 497 |
| ExternalDocumentID | 2588333031 A358700704 10_1007_s11062_012_9254_4 |
| GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C -~X .86 .GJ .VR 06C 06D 0R~ 0VY 123 1N0 1SB 2.D 28- 29N 29~ 2J2 2JN 2JY 2KG 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5QI 5RE 5VS 642 67N 67Z 6NX 7RV 7X7 88A 8AO 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AAFGU AAHNG AAIAL AAJKR AANXM AANZL AAPBV AARHV AARTL AATNV AATVU AAUYE AAWCG AAYFA AAYIU AAYQN AAYTO ABBBX ABBXA ABDBF ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABJNI ABJOX ABKAS ABKCH ABKTR ABMNI ABMQK ABNWP ABPTK ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACBMV ACBRV ACBYP ACGFS ACHSB ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACSNA ACTTH ACVWB ACWMK ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADMDM ADOAH ADOXG ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEEQQ AEFIE AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AENEX AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFEXP AFGCZ AFKRA AFLOW AFNRJ AFQWF AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQMX AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AKQUC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG AOSHJ ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BKEYQ BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EN4 EPAXT ESBYG EX3 F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GXS HCIFZ HF~ HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ IAO IHE IJ- IKXTQ INH INR IPY ISR ITC IWAJR IXC IXD IXE IZIGR IZQ I~X I~Z J-C JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LK8 LLZTM M0L M2M M4Y M7P MA- N2Q NAPCQ NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 PF0 PQQKQ PROAC PSYQQ PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI RNS ROL RPX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW STPWE SZN T13 T16 TEORI TSG TSK TSV TUC TUS U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 WOW XJT XU3 YLTOR ZGI ZMTXR ZOVNA ~A9 ~EX ~KM AACDK AAEOY AAJBT AAQLM AASML AAYXX ABAKF ACAOD ACDTI ACZOJ AEFQL AEMSY AFBBN AGQEE AGRTI AIGIU ALIPV CITATION H13 AAYZH 7TK 7XB 8FK K9. PQEST PQUKI PRINS Q9U |
| ID | FETCH-LOGICAL-c438t-f1693dd0e6d9c5850e36b20419d08d19f1f643176bc6fc0ed1c929ebfa7080d73 |
| IEDL.DBID | AGYKE |
| ISSN | 0090-2977 |
| IngestDate | Fri Oct 25 02:53:26 EDT 2024 Thu Oct 10 16:03:10 EDT 2024 Tue Nov 12 22:52:34 EST 2024 Thu Aug 01 20:24:45 EDT 2024 Thu Sep 12 16:56:30 EDT 2024 Sat Dec 16 12:04:40 EST 2023 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | cyclophilin D mitochondria porin cadmium-induced nonspecific mitochondrial permeability ADP/ATP antiporter |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c438t-f1693dd0e6d9c5850e36b20419d08d19f1f643176bc6fc0ed1c929ebfa7080d73 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
| PQID | 921728432 |
| PQPubID | 48806 |
| PageCount | 4 |
| ParticipantIDs | proquest_miscellaneous_926889386 proquest_journals_921728432 gale_infotracacademiconefile_A358700704 gale_incontextgauss_ISR_A358700704 crossref_primary_10_1007_s11062_012_9254_4 springer_journals_10_1007_s11062_012_9254_4 |
| PublicationCentury | 2000 |
| PublicationDate | 2012-03-01 |
| PublicationDateYYYYMMDD | 2012-03-01 |
| PublicationDate_xml | – month: 03 year: 2012 text: 2012-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Boston |
| PublicationPlace_xml | – name: Boston – name: New York |
| PublicationTitle | Neurophysiology (New York) |
| PublicationTitleAbbrev | Neurophysiology |
| PublicationYear | 2012 |
| Publisher | Springer US Springer Springer Nature B.V |
| Publisher_xml | – name: Springer US – name: Springer – name: Springer Nature B.V |
| References | Belyaeva, Glazunov, Nikitina, Korotkov (CR13) 2001; 33 Kravens’ka, Nalyvaiko, Fedirko, Dubyts’kii (CR9) 2008; 40 Fournier, Ducet, Crevat (CR6) 1987; 19 Schneider, Hogeboom (CR5) 1950; 183 Pourahmad, Mihajlovic, O’Brien (CR15) 2001; 500 Li, Xia, Jiang (CR18) 2003; 194 Chalmers, Nicholls (CR4) 2003; 278 Al-Nasser (CR17) 2000; 38 Hayes (CR1) 1997; 8 Zoratti, Szabo (CR2) 1995; 1241 Lee, Bork, Gholamrezaei, Thévenod (CR20) 2005; 288 Shih, Ko, Wu (CR16) 2004; 91 Zazueta, Sánchez, Garcнa, Correa (CR11) 2000; 32 Rasheed, Diwan, Sanadi (CR21) 1984; 144 Cleland (CR7) 1964; 3 Dorta, Leite, DeMarco (CR12) 2003; 97 Rasola, Bernardi (CR3) 2007; 12 Sundaram (CR8) 1974; 61 Belyaeva, Glazunov, Korotkov (CR14) 2002; 405 Lee, Spielmann, Bork, Thévenod (CR19) 2005; 289 Kravenskaya, Nalyvaiko, Dubyts’kii, Fedirko (CR10) 2009; 18 DJ Dorta (9254_CR12) 2003; 97 PV Sundaram (9254_CR8) 1974; 61 M Zoratti (9254_CR2) 1995; 1241 BK Rasheed (9254_CR21) 1984; 144 WW Cleland (9254_CR7) 1964; 3 EV Kravenskaya (9254_CR10) 2009; 18 EV Kravens’ka (9254_CR9) 2008; 40 EA Belyaeva (9254_CR14) 2002; 405 J Pourahmad (9254_CR15) 2001; 500 A Rasola (9254_CR3) 2007; 12 M Li (9254_CR18) 2003; 194 WK Lee (9254_CR20) 2005; 288 N Fournier (9254_CR6) 1987; 19 RB Hayes (9254_CR1) 1997; 8 C Zazueta (9254_CR11) 2000; 32 IA Al-Nasser (9254_CR17) 2000; 38 S Chalmers (9254_CR4) 2003; 278 EA Belyaeva (9254_CR13) 2001; 33 WK Lee (9254_CR19) 2005; 289 WC Schneider (9254_CR5) 1950; 183 CM Shih (9254_CR16) 2004; 91 |
| References_xml | – volume: 8 start-page: 371 issue: 13 year: 1997 end-page: 385 ident: CR1 article-title: The carcinogenicity of metals in humans publication-title: Cancer Causes Control doi: 10.1023/A:1018457305212 contributor: fullname: Hayes – volume: 1241 start-page: 139 issue: 2 year: 1995 end-page: 176 ident: CR2 article-title: The mitochondrial permeability transition publication-title: Biochim. Biophys. Acta. contributor: fullname: Szabo – volume: 278 start-page: 19062 issue: 21 year: 2003 end-page: 19070 ident: CR4 article-title: The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria publication-title: J. Biol. Chem. doi: 10.1074/jbc.M212661200 contributor: fullname: Nicholls – volume: 40 start-page: 252 issue: 4 year: 2008 end-page: 260 ident: CR9 article-title: Kinetic analysis of the calcium- and cadmium-induced development of nonspecific permeability of the mitochondrial inner membrane publication-title: Neurophysiology doi: 10.1007/s11062-009-9045-8 contributor: fullname: Dubyts’kii – volume: 288 start-page: F27 issue: 1 year: 2005 end-page: F39 ident: CR20 article-title: Cd -induced cytochrome release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca uniporter publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.00224.2004 contributor: fullname: Thévenod – volume: 97 start-page: 251 issue: 3 year: 2003 end-page: 257 ident: CR12 article-title: A proposed sequence of events for cadmium-induced mitochondrial impairment publication-title: J. Inorg. Biochem. doi: 10.1016/S0162-0134(03)00314-3 contributor: fullname: DeMarco – volume: 38 start-page: 407 issue: 4 year: 2000 end-page: 413 ident: CR17 article-title: Cadmium hepatotoxicity and alterations of the mitochondrial function publication-title: J. Toxicol. Clin. Toxicol. doi: 10.1081/CLT-100100950 contributor: fullname: Al-Nasser – volume: 289 start-page: C656 issue: 3 year: 2005 end-page: C664 ident: CR19 article-title: Cd -induced swelling-contraction dynamics in isolated kidney cortex mitochondria: role of Ca uniporter, K cycling, and protonmotive force publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00049.2005 contributor: fullname: Thévenod – volume: 3 start-page: 480 year: 1964 end-page: 482 ident: CR7 article-title: Dithiothreitol, a new protective reagent for SH groups publication-title: Biochemistry doi: 10.1021/bi00892a002 contributor: fullname: Cleland – volume: 194 start-page: 19 issue: 1/2 year: 2003 end-page: 33 ident: CR18 article-title: Cadmium directly induced the opening of membrane permeability pore of mitochondria which is possibly involved in cadmiumtriggered apoptosis publication-title: Toxicology doi: 10.1016/S0300-483X(03)00327-5 contributor: fullname: Jiang – volume: 405 start-page: 252 issue: 2 year: 2002 end-page: 264 ident: CR14 article-title: Cyclosporin A-sensitive permeability transition pore is involved in Cd -induced dysfunction of isolated rat liver mitochondria: doubts no more publication-title: Arch. Biochem. Biophys. doi: 10.1016/S0003-9861(02)00400-9 contributor: fullname: Korotkov – volume: 32 start-page: 1093 issue: 10 year: 2000 end-page: 1101 ident: CR11 article-title: Possible involvement of the adenine nucleotide translocase in the activation of the permeability transition pore induced by cadmium publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/S1357-2725(00)00041-8 contributor: fullname: Correa – volume: 12 start-page: 815 issue: 5 year: 2007 end-page: 833 ident: CR3 article-title: The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis publication-title: Apoptosis doi: 10.1007/s10495-007-0723-y contributor: fullname: Bernardi – volume: 144 start-page: 643 issue: 3 year: 1984 end-page: 647 ident: CR21 article-title: Activation of potassium ion transport in mitochondria by cadmium ion publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1984.tb08513.x contributor: fullname: Sanadi – volume: 33 start-page: 303 issue: 4 year: 2001 end-page: 318 ident: CR13 article-title: Bivalent metal ions modulate Cd effects on isolated rat liver mitochondria publication-title: J. Bioenerg. Biomembr. doi: 10.1023/A:1010607307099 contributor: fullname: Korotkov – volume: 500 start-page: 249 year: 2001 end-page: 252 ident: CR15 article-title: Hepatocyte lysis induced by environmental metal toxins may involve apoptotic death signals initiated by mitochondrial injury publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4615-0667-6_38 contributor: fullname: O’Brien – volume: 91 start-page: 384 issue: 2 year: 2004 end-page: 397 ident: CR16 article-title: Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts publication-title: J. Cell Biochem. doi: 10.1002/jcb.10761 contributor: fullname: Wu – volume: 183 start-page: 123 issue: 1 year: 1950 end-page: 128 ident: CR5 article-title: Intracellular distribution of enzymes. Further studies of the distribution of cytochrome in rat liver homogenates publication-title: J. Biol. Chem. contributor: fullname: Hogeboom – volume: 61 start-page: 717 issue: 2 year: 1974 end-page: 722 ident: CR8 article-title: A new method of coupling proteins to insoluble polymers publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(74)91016-X contributor: fullname: Sundaram – volume: 19 start-page: 297 issue: 3 year: 1987 end-page: 303 ident: CR6 article-title: Action of cyclosporine on mitochondrial calcium fluxes publication-title: J. Bioenerg. Biomembr. doi: 10.1007/BF00762419 contributor: fullname: Crevat – volume: 18 start-page: 19 issue: 1 year: 2009 end-page: 24 ident: CR10 article-title: Contribution of Na /Ca exchange to the processes of Ca - and Cd -induced activation of the mitochondrial permeability transition pore publication-title: Arkh. Klin. Éksp. Med. contributor: fullname: Fedirko – volume: 19 start-page: 297 issue: 3 year: 1987 ident: 9254_CR6 publication-title: J. Bioenerg. Biomembr. doi: 10.1007/BF00762419 contributor: fullname: N Fournier – volume: 32 start-page: 1093 issue: 10 year: 2000 ident: 9254_CR11 publication-title: Int. J. Biochem. Cell Biol. doi: 10.1016/S1357-2725(00)00041-8 contributor: fullname: C Zazueta – volume: 289 start-page: C656 issue: 3 year: 2005 ident: 9254_CR19 publication-title: Am. J. Physiol. Cell Physiol. doi: 10.1152/ajpcell.00049.2005 contributor: fullname: WK Lee – volume: 97 start-page: 251 issue: 3 year: 2003 ident: 9254_CR12 publication-title: J. Inorg. Biochem. doi: 10.1016/S0162-0134(03)00314-3 contributor: fullname: DJ Dorta – volume: 91 start-page: 384 issue: 2 year: 2004 ident: 9254_CR16 publication-title: J. Cell Biochem. doi: 10.1002/jcb.10761 contributor: fullname: CM Shih – volume: 405 start-page: 252 issue: 2 year: 2002 ident: 9254_CR14 publication-title: Arch. Biochem. Biophys. doi: 10.1016/S0003-9861(02)00400-9 contributor: fullname: EA Belyaeva – volume: 12 start-page: 815 issue: 5 year: 2007 ident: 9254_CR3 publication-title: Apoptosis doi: 10.1007/s10495-007-0723-y contributor: fullname: A Rasola – volume: 61 start-page: 717 issue: 2 year: 1974 ident: 9254_CR8 publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/0006-291X(74)91016-X contributor: fullname: PV Sundaram – volume: 18 start-page: 19 issue: 1 year: 2009 ident: 9254_CR10 publication-title: Arkh. Klin. Éksp. Med. contributor: fullname: EV Kravenskaya – volume: 144 start-page: 643 issue: 3 year: 1984 ident: 9254_CR21 publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1984.tb08513.x contributor: fullname: BK Rasheed – volume: 278 start-page: 19062 issue: 21 year: 2003 ident: 9254_CR4 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M212661200 contributor: fullname: S Chalmers – volume: 500 start-page: 249 year: 2001 ident: 9254_CR15 publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4615-0667-6_38 contributor: fullname: J Pourahmad – volume: 194 start-page: 19 issue: 1/2 year: 2003 ident: 9254_CR18 publication-title: Toxicology doi: 10.1016/S0300-483X(03)00327-5 contributor: fullname: M Li – volume: 33 start-page: 303 issue: 4 year: 2001 ident: 9254_CR13 publication-title: J. Bioenerg. Biomembr. doi: 10.1023/A:1010607307099 contributor: fullname: EA Belyaeva – volume: 288 start-page: F27 issue: 1 year: 2005 ident: 9254_CR20 publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.00224.2004 contributor: fullname: WK Lee – volume: 1241 start-page: 139 issue: 2 year: 1995 ident: 9254_CR2 publication-title: Biochim. Biophys. Acta. doi: 10.1016/0304-4157(95)00003-A contributor: fullname: M Zoratti – volume: 40 start-page: 252 issue: 4 year: 2008 ident: 9254_CR9 publication-title: Neurophysiology doi: 10.1007/s11062-009-9045-8 contributor: fullname: EV Kravens’ka – volume: 38 start-page: 407 issue: 4 year: 2000 ident: 9254_CR17 publication-title: J. Toxicol. Clin. Toxicol. doi: 10.1081/CLT-100100950 contributor: fullname: IA Al-Nasser – volume: 8 start-page: 371 issue: 13 year: 1997 ident: 9254_CR1 publication-title: Cancer Causes Control doi: 10.1023/A:1018457305212 contributor: fullname: RB Hayes – volume: 3 start-page: 480 year: 1964 ident: 9254_CR7 publication-title: Biochemistry doi: 10.1021/bi00892a002 contributor: fullname: WW Cleland – volume: 183 start-page: 123 issue: 1 year: 1950 ident: 9254_CR5 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)56449-8 contributor: fullname: WC Schneider |
| SSID | ssj0006895 |
| Score | 1.8625249 |
| Snippet | In mitochondria obtained from the rat liver, we confirmed the ability of Cd
2+
to induce the development of nonspecific mitochondrial permeability (NMP). A... In mitochondria obtained from the rat liver, we confirmed the ability of [Cd.sup.2+] to induce the development of nonspecific mitochondrial permeability (NMP).... In mitochondria obtained from the rat liver, we confirmed the ability of Cd^sup 2+^ to induce the development of nonspecific mitochondrial permeability (NMP).... In mitochondria obtained from the rat liver, we confirmed the ability of Cd super(2+) to induce the development of nonspecific mitochondrial permeability... |
| SourceID | proquest gale crossref springer |
| SourceType | Aggregation Database Publisher |
| StartPage | 494 |
| SubjectTerms | Analysis ATP Biomedical and Life Sciences Biomedicine Cadmium Kinetics Liver Membrane permeability Mitochondria Mitochondrial DNA Molecular biology Molecular modelling Neurosciences Peptidylprolyl isomerase Permeability Physiological aspects Pores Porins |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3faxQxEB70-uKL1FbxbJUgoqAEd7N72eRJztJShTtKtdC3kM0PuYfbbbt3D_3vO7OXvVKLPi3LhmyYTL58k5nMAHyoY67sRFS8yhwaKLII3Gqv8DWPQlRR15Y8urO5PL0of15OLlNsTpfCKgdM7IHat47OyL_qvpJSWYhvV9ecikaRczVV0HgKOwINhWwEO9-P52fnWyiWSm9KGOiMC2Q6g1uzvzuHxhBFJQiu0Uji5YON6W94fuQn7befk114nngjm24m-gU8Cc0e7E8btJmXt-wj6yM5-yPyfZjPhpq3bBboZu-iW3asjezI-uViveRUr8MFz-aoclR_Pi4cm-HSRihsPGkkO0PADpsU3rcv4eLk-PfRKU91E7grC7XikRKseJ8F6bVDcyALhaxFVubaZ8rnOuZREm-QtZPRZcHnDklSqKOtkD_6qngFo6ZtwmtgVkXsIY9OO1VaPVFROXxE5CkUjBXG8HkQmrnapMcw94mQScIGJWxIwqYcw3sSq6G0Ew3Ftfyx664zP36dm2kxQeBA-MFGn1Kj2K5urLPpmgCOhzJVPWh5MEyPSQuvM1s1GQPbfsUVQ24Q24R2TU2kQpam5Bi-DJN638E_R__mv787gGeCdKmPTjuE0epmHd4iXVnV75JS3gGiWeY6 priority: 102 providerName: ProQuest |
| Title | Molecular Mechanisms of Cadmium-Induced Nonspecific Mitochondrial Permeability |
| URI | https://link.springer.com/article/10.1007/s11062-012-9254-4 https://www.proquest.com/docview/921728432 https://search.proquest.com/docview/926889386 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELb6uHCBQkEsLZWFEEggrxIn69jHUG1bQLuqCistp8jxo1pVm0VNcii_npk8dtXXoacoychxPPZ4xjPzDSEfcx9KPeIJSwIDBoqIHNPKSrgNPeeJV7lGj-5kKs5m8Y_5aL5F-Proorga9h7JRlBvct3AeMEoAs4UGDUs3ia7Xd7pbnr65-d4LX-FVG3dAhUwDupN78t8qJFbu9FdmXzPOdrsOScv2jzAsoEqxFCTq2Fd5UPz7z6Q4xN-Z48871RQmrZz5iXZcsUrsp8WYH4vb-gn2gSFNqft-2Q66cvn0onDJOFFuSzpytNjbZeLesmw9Idxlk5h9mIpe78wdAJSAqRqYXFy03OQ_a5FA795TWYn49_HZ6wrwcBMHMmKecRqsTZwwioDlkXgIpHzIA6VDaQNlQ-9QBVE5EZ4EzgbGtC3XO51AqqoTaI3ZKdYFe4toVp6aCH0RhkZazWSXhq4eFB5MK7LDciXnhXZ3xZpI9tgKuNoZTBaGY5WFg_IB2RWhggWBYbIXOq6LLPvvy6yNBqBDAJJBkSfOyK_qq610V3GAfQHQa9uUR70TM-6NVzCl7B2VxzxAaHrt7D40KOiC7eqkURIUPikGJCvPZs3DTza-3dPoj4gzzjOkybw7ZDsVNe1ew-aUJUfke1knhx1CwCu38bT8wt4OuPpf2rxAQ8 |
| link.rule.ids | 315,783,787,12068,21400,27936,27937,31731,31732,33756,33757,41093,41535,42162,42604,43322,43817,52123,52246 |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1La9wwEB7a9NBeSh4t3eYlSkmhRdSvlaVTWELCpo2X0CawNyHrUfawdhrvHvLvM-O1NySlORljIYvRaPSNZjQfwOcyxNIMk5znkUUHRaSeG-UkvsYhSfKgSkMR3WIixtfZj-lw2uXmNF1aZW8TW0Ptaktn5N9Vy6SUpcnxzV9OpFEUXO0YNF7CKyrDRQQG-XTtb0VCqhWBgYp4gjinD2q2N-fQFaKchIQrdJF49mhbemqc_4mStpvP2Sa87VAjG62meQte-GobdkYVeszzO3bE2jzO9oB8ByZFz3jLCk_3emfNvGF1YCfGzWfLOSe2Dusdm6DCEft8mFlW4MJGQ1g50kd2iebarwp4372D67PTq5Mx71gTuM1SueCByqs4F3nhlEVnIPKpKJMoi5WLpItViIMg1CBKK4KNvIstQiRfBpMjenR5-h42qrryH4AZGbCHOFhlZWbUUAZp8REQpVAqlh_A115o-mZVHEM_lEEmCWuUsCYJ62wAn0ismopOVJTV8scsm0af__6lR-kQzQYaH2z0pWsU6sWtsaa7JIDjoTpVj1ru9tOju2XX6LWSDICtv-J6oSCIqXy9pCZCIkaTYgDf-kl96OC_o__47O8O4fX4qrjQF-eTn7vwJiG9avPU9mBjcbv0-whcFuVBq573rpXnxQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VVkJcUKEglhZqIQQSyGriZB37uCpdtcCuKmCl3izHD7SHzVZN9tB_z0weXZXHgVMUZeRY4_H4G88L4G0ZU2XHouBF4tBAkVngVnuFr2kUooi6tOTRnc3l-SL_fDW-6vuc1kO0--CS7HIaqEpT1Zxc-3iyTXxDS4ZCCgTXaOHw_AHs4UmUUUzfQkzuVLFUumthoBMuEOkMbs2_DXHvYPpdPf_hJ22Pn-k-PO5xI5t0C_0EdkL1FA4mFdrMq1v2jrWRnO0V-QHMZ0PPWzYLlNm7rFc1W0d2av1quVlx6tfhgmdzFDnqPx-Xjs1wa6MqrDxJJLtEhR26Et63z2AxPftxes77vgnc5ZlqeKQCK94nQXrt0BxIQiZLkeSp9onyqY5plIQbZOlkdEnwqUOQFMpoC8SPvsiew261rsILYFZFHCGNTjuVWz1WUTl8RMQpFIwVRvBhYJq57spjmG0hZOKwQQ4b4rDJR_CG2Gqo7ERFcS0_7aauzcX3b2aSjVFxoPpBovc9UVw3N9bZPk0A50OVqu5RHg7LY_qNV-OfqOFWnokRsLuvuGPIDWKrsN4QiVSI0pQcwcdhUbcD_HP2L_-L-hgeXn6amq8X8y-H8EiQmLWBa0ew29xswitEMk35upXWX3Vj6PM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+Mechanisms+of+Cadmium-Induced+Nonspecific+Mitochondrial+Permeability&rft.jtitle=Neurophysiology+%28New+York%29&rft.au=Kravenskaya%2C+E.+V.&rft.au=Fedirko%2C+N.+V.&rft.date=2012-03-01&rft.pub=Springer+US&rft.issn=0090-2977&rft.eissn=1573-9007&rft.volume=43&rft.issue=6&rft.spage=494&rft.epage=497&rft_id=info:doi/10.1007%2Fs11062-012-9254-4&rft.externalDocID=10_1007_s11062_012_9254_4 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0090-2977&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0090-2977&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0090-2977&client=summon |