Molecular Mechanisms of Cadmium-Induced Nonspecific Mitochondrial Permeability

In mitochondria obtained from the rat liver, we confirmed the ability of Cd 2+ to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochon...

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Published inNeurophysiology (New York) Vol. 43; no. 6; pp. 494 - 497
Main Authors Kravenskaya, E. V., Fedirko, N. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.03.2012
Springer
Springer Nature B.V
Subjects
Analysis
ATP
Biomedical and Life Sciences
Biomedicine
Cadmium
Kinetics
Liver
Membrane permeability
Mitochondria
Mitochondrial DNA
Molecular biology
Molecular modelling
Neurosciences
Peptidylprolyl isomerase
Permeability
Physiological aspects
Pores
Porins
cyclophilin D
mitochondria
porin
cadmium-induced nonspecific mitochondrial permeability
ADP/ATP antiporter
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Summary:In mitochondria obtained from the rat liver, we confirmed the ability of Cd 2+ to induce the development of nonspecific mitochondrial permeability (NMP). A kinetic analysis of this process was performed. We demonstrated that the cadmium-induced NMP is mediated by activation of megachannels (mitochondrial transition permeability pores) and is realized with the participation of porin, the ADP/ATP antiporter, and cyclophilin D. A key event in the process of induction of the mitochondrial pore opening is interaction of Cd 2+ with just the ADP/ATP antiporter.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-012-9254-4