Total synthesis of 1-oxomiltirone via Suzuki coupling

• Published in: Natural products and bioprospecting Vol. 3; no. 3; pp. 117 - 120
• Main Authors: Li, Chun-Miao, Geng, Hui-Chun, Li, Ming-Ming, Xu, Gang, Ling, Tie-Jun, Qin, Hong-Bo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2013; Springer Berlin Heidelberg; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Bioorganic Chemistry; diterpenoids; drugs; Food Science; Life Sciences; Medicinal Chemistry; Pharmacology/Toxicology; Plant Biochemistry; Plant Sciences; Short Communication; synthesis; Suzuki coupling; 1-oxomiltirone; abietane diterpenes; total synthesis; versatile intermediate

Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees...