Total synthesis of 1-oxomiltirone via Suzuki coupling

Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees...

Full description

Saved in:
Bibliographic Details
Published inNatural products and bioprospecting Vol. 3; no. 3; pp. 117 - 120
Main Authors Li, Chun-Miao, Geng, Hui-Chun, Li, Ming-Ming, Xu, Gang, Ling, Tie-Jun, Qin, Hong-Bo
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.06.2013
Springer Berlin Heidelberg
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Bioorganic Chemistry
diterpenoids
drugs
Food Science
Life Sciences
Medicinal Chemistry
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Short Communication
synthesis
Suzuki coupling
1-oxomiltirone
abietane diterpenes
total synthesis
versatile intermediate
Online AccessGet full text

Cover

More Information
Summary:Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4, a versatile intermediate 6 was found. The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization, and total synthesis of 1-oxomiltirone (1) has been achieved.
Bibliography:http://dx.doi.org/10.1007/s13659-013-0034-7
ISSN:2192-2209
2192-2195
2192-2209
DOI:10.1007/s13659-013-0034-7