Investigating into anti-cancer potential of lycopene: Molecular targets

• Published in: Biomedicine & pharmacotherapy Vol. 138; p. 111546
• Main Authors: Qi, Wang Jia, Sheng, Wang Shi, Peng, Chu, Xiaodong, Ma, Yao, Tang Ze
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.06.2021
• Subjects: Anticancer agent; Carotenoid; Lycopene; Molecular mechanisms; Anticancer agent; Carotenoid; Lycopene; Molecular mechanisms
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2021.111546

Lycopene, the main pigment of tomatoes, possess the strongest antioxidant activity among carotenoids. Lycopene has unique structure and chemical properties. We searched the literature, via PubMed, Embase, Web of Science and Google database so on to screen citations from inception to Oct 2020 for inclusion in this study. We found that as a common phytochemical, it did not attract much attention in the past few years. However, recent studies have indicated that, in addition to antioxidant activity and the second stage of detoxification, the anticancer of lycopene is also considered to be an important determinant of tumor development including the inhibition of cell proliferation, inhibition of cell cycle progression, induction of apoptosis, inhibition of cell invasion, angiogenesis and metastasis. The effect mechanisms of lycopene are related to the regulation of several signal transduction pathways, such as PI3K/Akt pathway, modulation of insulin-like growth factors system, the suppression of activity of sex steroid hormones, the modification of relevant gene expression, and the alteration of mitochondrial function. These novel findings have suggested that lycopene acts as a promising functional natural pigment, and may be associated with a decreased risk of different types of cancer. This review presents the latest knowledge with respect to its molecular mechanisms and its molecular targets of the inhibitory effects on carcinogenesis.