Primary Tumor Score Based on Tumor Depth and Length Predicts Prognosis in Esophageal Squamous Cell Carcinoma

• Published in: Anticancer research Vol. 38; no. 9; pp. 5447 - 5452
• Main Authors: Arigami, Takaaki, Uchikado, Yasuto, Omoto, Itaru, Sasaki, Ken, Kita, Yoshiaki, Owaki, Tetsuhiro, Yanagita, Shigehiro, Mori, Shinichiro, Kurahara, Hiroshi, Okumura, Hiroshi, Maemura, Kosei, Natsugoe, Shoji
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.09.2018
• Subjects: Abnormalities; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Chi-Square Distribution; Decision Support Techniques; Esophageal cancer; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophageal Squamous Cell Carcinoma; Esophagus; Female; Humans; Kaplan-Meier Estimate; Lymph nodes; Lymphatic Metastasis; Male; Metastases; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Staging; Patients; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Squamous cell carcinoma; Tumor Burden; Tumors; Primary tumor score; esophageal squamous cell carcinoma; depth of tumor invasion; prognosis; tumor length
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.12876

To examine the depth of tumor invasion and tumor length and assess the clinical impact of the primary tumor score (PTS), based on a combination of tumor invasion and tumor length, in patients with esophageal squamous cell carcinoma (ESCC). A total of 237 patients with ESCC were classified into three PTS groups based on cut-off values for deeper tumor invasion (pT2-T4) and greater tumor length (≥44 mm). A PTS of 2 indicated the presence of both of these abnormalities, 1 indicated one of these abnormalities, and 0 indicated neither abnormality. PTS was significantly positively correlated with depth of tumor invasion, lymph node metastasis, lymphovascular invasion, and stage (all p<0.001). The prognosis differed significantly among the three groups based on PTS (p<0.0001). Multivariate analysis demonstrated that PTS was an independent prognostic factor (p=0.0004). PTS has a clinical utility as a prognostic predictor in patients with ESCC.