Association of fetuin-A with dyslipidemia and insulin resistance in type-II Diabetics of Pakistani population

• Published in: Pakistan journal of medical sciences Vol. 36; no. 2; pp. 64 - 68
• Main Authors: Fatima, Fasiha, Ahsan, Naveed, Nasim, Aliya, Alam, Faiza
• Format: Journal Article
• Language: English
• Published: Pakistan Knowledge Bylanes 01.01.2020; AsiaNet Pakistan (Pvt) Ltd; Professional Medical Publications
• Subjects: Age; Anopheles; Atherosclerosis; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Coronary heart disease; Diabetes; Diabetes mellitus; Diabetic neuropathies; Diabetic neuropathy; Diabetic retinopathy; Diabetics; Diseases; Fasting; Glucose; Hyperglycemia; Hyperlipidemia; Hypertension; Hypoglycemic agents; Immunoassay; Insulin resistance; Kidney diseases; Lipids; Low density lipoprotein; Metabolic disorders; Metabolic syndrome; Original; Phenols; Statistical analysis; Studies; Triglycerides; Belgium; France; fetuin-A; Insulin resistance; Type-II diabetes mellitus mellitus; Dyslipidemia
• ISSN: 1682-024X; 1681-715X
• DOI: 10.12669/pjms.36.2.1106

Fetuin-A, hepatokine is responsible for instigating insulin resistance by inhibiting tyrosine kinase receptors. Our objective was to investigate the relationship of fetuin-A with dyslipidemia and insulin resistance in type-II diabetics of Pakistani population. In this cross sectional study which was conducted at Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi between October 2013 to March 2014, a total of 330 participants were selected and divided into two groups. Group-A (n = 165) normal healthy individual and Group-B (n = 165) Type-II diabetes mellitus mellitus with no comorbidities. Serum fetuin-A and insulin levels were determined by commercially prepared ELISA kits while fasting blood glucose (FBG) and lipid profile were performed by enzymatic kit method. Employing independent t-test, comparison of groups was done and correlation was achieved by using spearman correlation. The results demonstrate a significant difference in mean values of fetuin-A, lipid profile, glucose, insulin and Homoeostasis Model Assessment of Insulin resistance (HOMA-IR) in type-II diabetics when compared to normal healthy individuals (p<0.01). A positive correlation was found between serum fetuin-A levels and FBG(r= 0.495, p< 0.001), insulin(r= 0.227, p< 0.001), HOMA-IR(r= 0.336, p<0.001, triglycerides(r= 0.197, p< 0.001) and LDL-cholesterol(r= 0.170, p= 0.002), while negative correlation with HDL-cholesterol(r= -0.251, p< 0.001). The study concludes that fetuin-A might be accountable for dyslipidemia and insulin resistance in type-II diabetes mellitus mellitus. So the high levels of Fetuin-A responsible for insulin resistance might alters endothelium and causes inflammation, vasoconstriction and thrombosis and ultimately atherosclerosis.