Ventricular tachycardia and ventricular fibrillation in a young population

• Published in: Circulation (New York, N.Y.) Vol. 60; no. 5; pp. 988 - 997
• Main Authors: Pedersen, D H, Zipes, D P, Foster, P R, Troup, P J
• Format: Journal Article
• Language: English
• Published: United States 01.11.1979
• Subjects: Adolescent; Adult; Aging; Cardiomyopathies - diagnosis; Child; Electrocardiography; Electrophysiology; Exercise Test; Female; Heart Defects, Congenital - diagnosis; Heart Diseases - diagnosis; Heart Ventricles - physiopathology; Humans; Infant; Infant, Newborn; Male; Mitral Valve Prolapse - diagnosis; Myocarditis - diagnosis; Myocardium - pathology; Tachycardia - diagnosis; Ventricular Fibrillation - diagnosis
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/01.cir.60.5.988

In this study, we describe the findings in 18 young patients (age range 4 days to 24 years, mean 16.6 years) who had ventricular tachycardia and/or ventricular fibrillation and were followed for 4--70 months (mean 22.4 months). Patients had a variety of problems associated with their arrhythmia, including mitral valve prolapse, cardiomyopathy, myocarditis, prolonged QT syndrome and hypokalemia. Six patients had no clinically recognizable cardiac abnormality. The ventricular tachycardia showed a left bundle branch block contour in 10 of 17 patients, right bundle branch block in four, was multiform in two and had an indeterminate contour in one. Sustained ventricular tachycardia was initiated and terminated reproducibly by atrial and ventricular stimulation in three of seven patients who did not have spontaneous episodes of ventricular tachycardia during the electrophysiologic study. In one other patient, short bursts of ventricular tachycardia were induced. Patients who had ventricular fibrillation, those who died, and those who are still symptomatic with poorly controlled ventricular arrhythmias had significant heart disease. In one patient, a ventricular tachyarrhythmia that had required more than 100 electrical cardioversions spontaneously disappeared after requiring 1 year of antiarrhythmic therapy.