Combined small bowel and reduced auxiliary liver transplantation：case report

• Published in: World journal of gastroenterology : WJG Vol. 8; no. 5; pp. 956 - 960
• Main Authors: Zhang, Wei-Jie, Liu, Dun-Gui, Ye, Qi-Fa, Sha, Bo, Zhen, Fan-Jun, Guo, Hui, Xia, Sui-Sheng
• Format: Journal Article
• Language: English
• Published: United States Institute of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan. 430030, Hubei Province, China 01.10.2002; Baishideng Publishing Group Inc
• Subjects: Clinical Research; Fatal Outcome; Graft Rejection - pathology; Humans; Intestine, Small - transplantation; Liver Transplantation; Male; Middle Aged; Postoperative Complications - pathology; Short Bowel Syndrome - surgery; TPN相关性肝功能不良; 合并症; 小肠移植; 短肠综合征; 肝移植
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v8.i5.956

AIM：To present a case of combined small bowel and reduced auxiliary liver transplantation.METHODS:A55-year-old patient with short bowel syndrome and TPN-related liver dysfunction received small bowel transplantation combined with a reduced auxiliary liver graft.A liver was added to restor the patient's liver function and to protect the intestinal allograft from rejection.His own liver was not removed.RESULTS:Without donor pretreatment and by conventional immunosuppresive therapy following transplantation,the patient exparienced had only one episode of mild intestinal rejection,which was easily reversed by treatment with Methylprednisolone,No liver rejection occurred.Unfortunately,the patient died of heart and lung failure 30d after transplantation,despite successful graft replacement,Histopathologic examination of specimens after death demonstrated normal structure in both intestinal and liver grafts.CONCLUSION:The auxiliary liver graft might play a role in preventing intestinal allograft rejection.However,the observation periol in this case is short.Further study is needed to determine the risks ,effect on the protecting the small-bowel from rejection,and feasibility of general application of this procedure.