Mitochondrial Localization of CB1 in Progesterone-producing Cells of Ovarian Interstitial Glands of Adult Mice

Localization of cannabinoid receptor type 1 (CB1) immunoreactivity on mitochondrial membranes, at least their outer membranes distinctly, was detected in progesterone-producing cells characterized by mitochondria having tubular cristae and aggregations of lipid droplets in ovarian interstitial gland...

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Published inThe journal of histochemistry and cytochemistry Vol. 70; no. 3; pp. 251 - 257
Main Authors Kamnate, Anussara, Sirisin, Juthathip, Watanabe, Masahiko, Kondo, Hisatake, Hipkaeo, Wiphawi, Chomphoo, Surang
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.03.2022
Subjects
Advances in Brief
Animals
Female
Mice
Mice, Inbred ICR
Mitochondria - chemistry
Mitochondria - immunology
Ovary - chemistry
Ovary - cytology
Ovary - immunology
Progesterone - biosynthesis
Receptor, Cannabinoid, CB1 - analysis
Receptor, Cannabinoid, CB1 - immunology
ovary
CB1
steroidogenic cell
mitochondria
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Summary:Localization of cannabinoid receptor type 1 (CB1) immunoreactivity on mitochondrial membranes, at least their outer membranes distinctly, was detected in progesterone-producing cells characterized by mitochondria having tubular cristae and aggregations of lipid droplets in ovarian interstitial glands in situ of adult mice. Both immunoreactive and immunonegative mitochondria were contained in one and the same cell. Considering that the synthesis of progesterone is processed in mitochondria, the mitochondrial localization of CB1 in the interstitial gland cells suggests the possibility that endocannabinoids modulate the synthetic process of progesterone in the cells through CB1:
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-1554
1551-5044
DOI:10.1369/00221554211063516