Modulating the transcriptional control of adipogenesis

• Published in: Current opinion in genetics & development Vol. 7; no. 5; pp. 603 - 608
• Main Authors: Loftus, Thomas M, Lane, M Daniel
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.10.1997
• Subjects: Adipocytes - physiology; Adipose Tissue - embryology; Adipose Tissue - physiology; Animals; CCAAT-Enhancer-Binding Proteins; DNA-Binding Proteins - biosynthesis; DNA-Binding Proteins - metabolism; Gene Expression Regulation; Gene Expression Regulation, Developmental; Humans; Nuclear Proteins - biosynthesis; Nuclear Proteins - metabolism; Obesity - physiopathology; Receptors, Cytoplasmic and Nuclear - biosynthesis; Receptors, Cytoplasmic and Nuclear - metabolism; Transcription Factors - biosynthesis; Transcription Factors - metabolism; Transcription, Genetic; SCD1 stearoyl-CoA desaturase 1; SREBP sterol regulatory element binding protein: TNFα tumor necrosis factor α; gadd45 growth arrest and DNA damage inducible gene 45; PPAR peroxisome proliferator activated receptor; ADD adipocyte determination and differentiation-dependent; EGF epidermal growth factor; RXR retinoid X receptor; PDGF platelet-derived growth factor; Rb retinoblastoma; C/EBP CAAT/enhancer-binding protein; RAR retinoic acid receptor
• ISSN: 0959-437X; 1879-0380
• DOI: 10.1016/S0959-437X(97)80006-8

Current evidence indcates that much of the regulation of adipocyte differentiation serves to modulate a common adipogenic transcriptional control pathway, comprising members of the C/EBP and PPAR families. Hormonal regulators have been found to control expression of these factors and to alter their activity through ligand binding, post-transcriptional modification, and protein-protein interactions.