Stretch-activated channels in the heart: Contributions to length-dependence and to cardiomyopathy

• Published in: Progress in biophysics and molecular biology Vol. 97; no. 2; pp. 232 - 249
• Main Authors: Ward, Marie-Louise, Williams, Iwan A., Chu, Yi, Cooper, Patricia J., Ju, Yue-Kun, Allen, David G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2008
• Subjects: Animals; Calcium - physiology; Cardiac myocytes; Cardiomyopathy, Dilated - metabolism; Cardiomyopathy, Dilated - physiopathology; Heart Ventricles - cytology; Heart Ventricles - drug effects; Heart Ventricles - physiopathology; Ion Channel Gating - drug effects; Ion Channels - drug effects; Ion Channels - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscular dystrophy; Myocardial Contraction - drug effects; Myocardial Contraction - physiology; Myocytes, Cardiac - drug effects; Myocytes, Cardiac - physiology; Peptides - pharmacology; Protein expression; Spider Venoms - pharmacology; Streptomycin - pharmacology; Stress, Mechanical; Stretch-activated ion channels; Trabeculae; Protein expression; Trabeculae; Stretch-activated ion channels; Cardiac myocytes; Muscular dystrophy

The stretch-induced increase in force production of ventricular muscle is biphasic. An abrupt increase in force coincides with the stretch, which is then followed by a slower response that develops over minutes (the slow force response or SFR). The SFR is accompanied by a slow increase in the magnit...