The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass

• Published in: The International Journal of Cardiovascular Imaging Vol. 34; no. 11; pp. 1715 - 1723
• Main Authors: Shiba, Tomoaki, Takahashi, Mao, Shiba, Chieko, Matsumoto, Tadashi, Hori, Yuichi
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.11.2018; Springer Nature B.V
• Subjects: Acceleration; Aged; Blood Flow Velocity; Blood pressure; Blood vessels; Body mass; Body mass index; Body size; Cardiac Imaging; Cardiology; Cross-Sectional Studies; Diastolic pressure; Doppler effect; Echocardiography; Echocardiography, Doppler, Color; Echocardiography, Doppler, Pulsed; Female; Heart; Humans; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - physiopathology; Imaging; Laser-Doppler Flowmetry; Male; Medicine; Medicine & Public Health; Microcirculation; Middle Aged; Multiple regression analysis; Optic Disk - blood supply; Optic nerve; Original Paper; Parameters; Predictive Value of Tests; Pressure ratio; Prognosis; Pulsatile Flow; Radiology; Regional Blood Flow; Regression analysis; Retrospective Studies; Ventricle; Ventricular Function, Left; Ventricular Pressure; Ventricular Remodeling; Left ventricular mass; E/e′ ratio; Echocardiography; Ocular circulation; Laser speckle flowgraphy
• ISSN: 1569-5794; 1573-0743; 1875-8312
• DOI: 10.1007/s10554-018-1388-z

To evaluate the relationships between parameters of the pulsatile flow form in the optic nerve head shown by laser speckle flowgraphy (LSFG) and the left ventricular (LV) end-diastolic pressure and mass obtained by echocardiography. We cross sectional analyzed the cases of 175 subjects who had undergone polysomnography. Standard M-mode two-dimensional color Doppler imaging was performed to evaluate the E/e′ ratio (which represents the LV end-diastolic pressure) and LV mass. The pulsatile flow form analysis parameters of the blowout score and acceleration time index were evaluated. The parameters were analyzed separately for the tissue, vessels and throughout the optic nerve head (All). We performed a single regression analysis and a multiple regression analysis to determine whether pulsatile flow form are independent factors for the E/e′ ratio and LV mass. The factors contributing independently to the E/e′ ratio were blowout time-Tissue (standard regression = − 0.27, t -value = − 2.90, p  < 0.0001) and body mass index (BMI) (0.16, 2.05, p  = 0.04). The factors that were shown to independently contribute to the LV mass were urinary albumin concentration (0.30, − 2.90, p  < 0.0001), BMI (0.28, 4.09, p  < 0.0001), differences of gender (men = 1, women = 0: 0.23, 3.28, p  = 0.001), acceleration time index-Vessel (− 0.23, − 2.99, p  = 0.003) and mean arterial blood pressure (0.17, 2.61, p  = 0.01). Our results confirmed that parameters of the pulsatile flow form of ocular microcirculation obtained by LSFG are significantly correlated with the LV end-diastolic pressure ratio and LV mass.