Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections

Alteration of macrophage function has an important regulatory impact on the survival of intracellular mycobacteria. We found that macrophages infected with attenuated Mycobacterium tuberculosis (Mtb) strain H37Ra had elevated expression of M1-related molecules, whereas the M2 phenotype was dominant...

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Published inScientific reports Vol. 6; no. 1; p. 37211
Main Authors Lim, Yun-Ji, Yi, Min-Hee, Choi, Ji-Ae, Lee, Junghwan, Han, Ji-Ye, Jo, Sung-Hee, Oh, Sung-Man, Cho, Hyun Jin, Kim, Dong Woon, Kang, Min-Woong, Song, Chang-Hwa
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.11.2016
Nature Publishing Group
Subjects
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Apoptosis
Endoplasmic reticulum
Humanities and Social Sciences
Immune response
Intracellular
Macrophages
multidisciplinary
Polarization
Science
Signal transduction
Tuberculosis
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Summary:Alteration of macrophage function has an important regulatory impact on the survival of intracellular mycobacteria. We found that macrophages infected with attenuated Mycobacterium tuberculosis (Mtb) strain H37Ra had elevated expression of M1-related molecules, whereas the M2 phenotype was dominant in macrophages infected with virulent Mtb H37Rv. Further, the TLR signalling pathway played an important role in modulating macrophage polarization against Mtb infection. Interestingly, endoplasmic reticulum (ER) stress was significantly increased in M1 polarized macrophages and these macrophages effectively removed intracellular Mtb, indicating that ER stress may be an important component of the host immune response to Mtb in M1 macrophages. This improved understanding of the mechanisms that regulate macrophage polarization could provide new therapeutic strategies for tuberculosis.
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ISSN:2045-2322
2045-2322
DOI:10.1038/srep37211