Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo

• Published in: Journal of antibiotics Vol. 62; no. 2; pp. 95 - 98
• Main Authors: Yamagishi, Yukiko, Ueno, Motoi, Ueno, Chihoko, Kato, Akemi, Kanasaki, Ryuichi, Sato, Bunji, Takakura, Koji, Fujie, Akihiko, Nakajima, Hidenori, Fujii, Takashi, Hino, Motohiro, Tsujii, Eisaku
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2009; Nature Publishing Group
• Subjects: Acyclovir - therapeutic use; Animals; Antibiotics; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Bridged-Ring Compounds; Carbohydrate Conformation; Carbohydrate Sequence; Cell Survival - drug effects; Cercopithecus aethiops; DNA, Viral - analysis; DNA, Viral - biosynthesis; DNA, Viral - genetics; Ethers; Female; Furans - pharmacology; Furans - therapeutic use; Ganglia, Spinal - chemistry; Ganglia, Spinal - virology; Herpes Simplex - drug therapy; Herpes Simplex - virology; Herpesvirus 1, Human - drug effects; Herpesvirus 2, Human - drug effects; Life Sciences; Medicinal Chemistry; Mice; Mice, Inbred BALB C; Microbiology; Molecular Sequence Data; Organic Chemistry; original-article; Pyrans - pharmacology; Pyrans - therapeutic use; Vero Cells; polyether; CP-44161; antiviral; herpes virus
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2008.18

In the previous study, we discovered a polyether antibiotic CP-44161, which was reported earlier as an anticoccidal agent, as an anti-varicella zoster virus compound. In this study, we demonstrated that CP-44161 had a very strong and broad anti-herpes virus activities against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro . To determine the antiviral activity of CP-44161 in vivo , we examined its effect on the cutaneous HSV-2 infection model in Balb/c mice. CP-44161 showed inhibitory effect on lesion development as well as acyclovir (ACV) when the treatment was started from day 3. Meanwhile, in case the start of treatment was delayed until day 4, when ACV was no longer effective, the effectiveness of CP-44161 still remained. In this model, CP-44161 also showed inhibitory effect on the proliferation of HSV-2 DNA in dorsal root ganglia. This is the first article to report that polyether antibiotics can be effective on viral infection in vivo .