Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis

Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions betwee...

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Published inOsteoporosis international Vol. 23; no. Suppl 8; pp. 841 - 846
Main Authors Mahjoub, M., Berenbaum, F., Houard, X.
Format Journal Article
LanguageEnglish
Published London Springer-Verlag 01.12.2012
Springer Nature B.V
Subjects
Arthritis
Bone and Bones - pathology
Bone and Bones - physiopathology
Bone Quality Seminars: Subchondral Bone
Bone Remodeling - physiology
Bones
Cartilage
Cartilage, Articular - pathology
Cartilage, Articular - physiopathology
Cell Differentiation
Chondrocytes - pathology
Endocrinology
Humans
Medicine
Medicine & Public Health
Orthopedics
Osteoarthritis - pathology
Osteoarthritis - physiopathology
Rheumatology
Vascular channels
Subchondral bone
Osteoarthritis
Hypertrophic chondrocytes
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Summary:Osteoarthritis is a whole joint disease characterised by the disappearance of the cartilage associated with subchondral bone sclerosis, formation of osteophytes and a mild inflammation of the synovial membrane. Although all these events have been independently studied, functional interactions between these different joint tissues should exist, especially between subchondral bone and cartilage. Moreover, recent studies show that cartilage and subchondral bone act as a single functional unit. This review highlights this novel concept.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-012-2161-0