Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer
Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed...
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Published in | Scientific reports Vol. 5; no. 1; p. 9247 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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18.03.2015
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Abstract | Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration and invasion, as well as decreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analyses revealed that depleting DHX32 in SW480 colon cancer cells suppressed expression of
WISP1
,
MMP7
and
VEGFA
in the Wnt pathway and anti-apoptotic gene
BCL2
and
CA9
, however, elevated expression of pro-apoptotic gene
ACSL5.
The findings suggested that overexpressed DHX32 played an important role in CRC progression and metastasis and that DHX32 has the potential to serve as a biomarker and a novel therapeutic target for CRC. |
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AbstractList | Abstract
Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration and invasion, as well as decreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analyses revealed that depleting DHX32 in SW480 colon cancer cells suppressed expression of
WISP1
,
MMP7
and
VEGFA
in the Wnt pathway and anti-apoptotic gene
BCL2
and
CA9
, however, elevated expression of pro-apoptotic gene
ACSL5.
The findings suggested that overexpressed DHX32 played an important role in CRC progression and metastasis and that DHX32 has the potential to serve as a biomarker and a novel therapeutic target for CRC. Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration, and invasion, as well as decreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analyses revealed that depleting DHX32 in SW480 colon cancer cells suppressed expression of WISP1 , MMP7 and VEGFA in the Wnt pathway, and anti-apoptotic gene BCL2 and CA9 , however, elevated expression of pro-apoptotic gene ACSL5. The findings suggested that overexpressed DHX32 played an important role in CRC progression and metastasis and that DHX32 has the potential to serve as a biomarker and a novel therapeutic target for CRC. Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32 contributes to CRC remains largely unknown. In this study, we reported that DHX32 was overexpressed in human colon cancer cells. Overexpressed DHX32 promoted SW480 cancer cells proliferation, migration, and invasion, as well as decreased the susceptibility to chemotherapy agent 5-Fluorouracil. Furthermore, PCR array analyses revealed that depleting DHX32 in SW480 colon cancer cells suppressed expression of WISP1, MMP7 and VEGFA in the Wnt pathway, and anti-apoptotic gene BCL2 and CA9, however, elevated expression of pro-apoptotic gene ACSL5. The findings suggested that overexpressed DHX32 played an important role in CRC progression and metastasis and that DHX32 has the potential to serve as a biomarker and a novel therapeutic target for CRC. |
ArticleNumber | 9247 |
Author | Liang, Xianming Bai, Yongying You, Hanyu Liu, Wenjuan Lin, Huayue Wang, Fen Li, Juan Zhang, Zhong-Ying Fang, Zanxi Lin, Lingqing Pei, Yihua |
Author_xml | – sequence: 1 givenname: Huayue surname: Lin fullname: Lin, Huayue organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 2 givenname: Wenjuan surname: Liu fullname: Liu, Wenjuan organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 3 givenname: Zanxi surname: Fang fullname: Fang, Zanxi organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 4 givenname: Xianming surname: Liang fullname: Liang, Xianming organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 5 givenname: Juan surname: Li fullname: Li, Juan organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 6 givenname: Yongying surname: Bai fullname: Bai, Yongying organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 7 givenname: Lingqing surname: Lin fullname: Lin, Lingqing organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 8 givenname: Hanyu surname: You fullname: You, Hanyu organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 9 givenname: Yihua surname: Pei fullname: Pei, Yihua organization: Central Laboratory, Xiamen University Affiliated Zhongshan Hospital – sequence: 10 givenname: Fen surname: Wang fullname: Wang, Fen organization: Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center – sequence: 11 givenname: Zhong-Ying surname: Zhang fullname: Zhang, Zhong-Ying organization: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University |
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Snippet | Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how overexpressed DHX32... Abstract Our previous work demonstrates that DHX32 is upregulated in colorectal cancer (CRC) compared to its adjacent normal tissues. However, how... |
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SubjectTerms | 13/1 13/109 13/2 13/31 13/89 13/95 14/63 38/61 5-Fluorouracil 631/67/395 631/80/86 Antigens, Neoplasm - metabolism Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Carbonic Anhydrase IX Carbonic Anhydrases - metabolism Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Chemotherapy Coenzyme A Ligases - metabolism Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DEAD-box RNA Helicases - antagonists & inhibitors DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Fluorouracil - pharmacology Humanities and Social Sciences Humans Matrilysin Metastases Metastasis multidisciplinary Polymerase chain reaction Proto-Oncogene Proteins c-bcr - metabolism RNA Interference RNA, Small Interfering - metabolism Science Up-Regulation - drug effects Wnt protein Wnt Signaling Pathway - drug effects |
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Title | Overexpression of DHX32 contributes to the growth and metastasis of colorectal cancer |
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