Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women

• Published in: Fertility and sterility Vol. 77; no. 4; pp. 666 - 668
• Main Authors: Calvo, Rosa M., Tellerı́a, Dolores, Sancho, José, San Millán, José L., Escobar-Morreale, Héctor F.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.04.2002; Elsevier Science
• Subjects: 17-alpha-Hydroxyprogesterone - blood; 23/Hph I; Adult; Alleles; Androstenedione - blood; Biological and medical sciences; Blood Glucose - analysis; Body Mass Index; Dehydroepiandrosterone Sulfate - blood; Endocrinopathies; Estradiol - blood; Female; General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes; hirsutism; Hirsutism - complications; Homozygote; Humans; hyperandrogenism; Hyperandrogenism - blood; Hyperandrogenism - complications; Hyperandrogenism - genetics; insulin; Insulin - blood; Insulin - genetics; Insulin Resistance; Medical sciences; Minisatellite Repeats - genetics; polycystic ovary syndrome; Polycystic Ovary Syndrome - complications; polymorphism; Polymorphism, Genetic - genetics; Sex Hormone-Binding Globulin - analysis; Spain; Testosterone - blood; Variable number of tandem repeats; VNTR; Europe; Spain; hirsutism; Variable number of tandem repeats; insulin; hyperandrogenism; polymorphism; 23/Hph I; VNTR; polycystic ovary syndrome; Endocrinopathy; Human; Hair; Pancreatic hormone; Skin disease; Hirsutism; Female sterility; Polycystic ovary; Tandemly repeated sequence; Insulin; Female genital diseases; Ovarian diseases; Cyst; Virilism; Female; Hyperandrogenism; Benign neoplasm; Polymorphism
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(01)03238-1

Objective: To determine if the insulin gene variable number of tandem repeats (VNTR) regulatory polymorphism is associated with hyperandrogenism in a population of Spanish women. Design: Controlled clinical study. Setting: Tertiary institutional hospital. Patient(s): Ninety-six hyperandrogenic patients and 38 healthy control women. Intervention(s): Whole blood and serum samples were collected during the follicular phase of the menstrual cycle. Main Outcome Measure(s): Insulin gene VNTR regulatory polymorphism genotypes (classes I/I, I/III, and III/III alleles) and serum androgen levels. Insulin resistance was estimated from fasting glucose and insulin levels by using the homeostatic model assessment. Result(s): The frequencies of VNTR genotypes were 45.5%, 43.3%, and 11.2% for I/I, I/III, and III/III alleles considering patients and controls as a whole. These frequencies were not statistically different in controls (47.4%, 34.2%, and 18.4%) and in patients (44.8%, 46.9%, and 8.3%). Conclusion(s): Hyperandrogenism and the insulin gene VNTR regulatory polymorphism are not associated in Spanish women.