Cytoplasmic genetic effects and growth of hybrid mice

Variation in cellular biochemical functions controlled by cytoplasmic genes was studied in relation to phenotypic differences between progeny of reciprocal hybrid female mice. Least squares procedures were used to test for differences in mitochondrial respiratory metabolism and in capacity for ATP s...

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Bibliographic Details
Published inJournal of animal science Vol. 67; no. 4; p. 887
Main Authors Brown, D.R. (Univ. of Florida, Gainesville), DeNise, S.K, McDaniel, R.G
Format Journal Article
LanguageEnglish
Published United States 01.04.1989
Subjects
Adenosine Triphosphate - biosynthesis
Adenosine Triphosphate - metabolism
Animals
CRECIMIENTO
CROISSANCE
Crosses, Genetic
Cytoplasm - physiology
CYTOPLASMIC INHERITANCE
Female
Genes
GROWTH
HEREDITE CYTOPLASMIQUE
HERENCIA CITOPLASMATICA
Hybridization, Genetic
Male
MATERNIDAD
MATERNITE
MATERNITY
MICE
Mice, Inbred A
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred DBA
MITOCHONDRIA
Mitochondria, Liver - analysis
Mitochondria, Liver - metabolism
MITOCHONDRIE
MITOCONDRIA
Oxidative Phosphorylation
Oxygen Consumption
Phenotype
RATON
SOURIS
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Summary:Variation in cellular biochemical functions controlled by cytoplasmic genes was studied in relation to phenotypic differences between progeny of reciprocal hybrid female mice. Least squares procedures were used to test for differences in mitochondrial respiratory metabolism and in capacity for ATP synthesis, and differences in growth of progeny of hybrid dams. Under identical nuclear influences, mitochondria of A/J and C57BL/6J cytoplasms differed (P less than .10 to P less than .01) from those of BALB/cJ cytoplasm in energy conservation. No differences were detected in mitochondrial efficiency between BALB/cJ cytoplasm evaluated in different nuclear environments. Three-way cross progeny of C57BL/6J x BALB/cJ reciprocal hybrid females mated to DBA/2J males differed (P less than .05) in litter weight at weaning and 1 wk and 2 wk postweaning. The F2 progeny of reciprocal C57BL/6J x BALB/cJ dams and F2 and three-way cross progeny of reciprocal A/J x BALB/cJ dams did not differ in weight at any age measured. Across all genotypes of dam, rank correlations of mitochondrial traits with F2 litter weights were nonsignificant. Observed variation in mitochondrial functions partially controlled by cytoplasmic genes did not limit mouse growth under these experimental conditions.
Bibliography:8931453
L10
ISSN:0021-8812
1525-3163
DOI:10.2527/jas1989.674887x