Natural killer cells in COVID-19: from infection, to vaccination and therapy

Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few...

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Bibliographic Details
Published inFuture virology
Main Authors Zafarani, Alireza, Razizadeh, Mohammad Hossein, Pashangzadeh, Salar, Amirzargar, Mohammad Reza, Taghavi-Farahabadi, Mahsa, Mahmoudi, Mohammad
Format Journal Article
LanguageEnglish
Published England 01.02.2023
Subjects
COVID-19
exhaustion
NK cells
SARS-CoV-2
vaccination
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Summary:Natural killer (NK) cells are among the most important innate immunity members, which are the first cells that fight against infected cells. The function of these cells is impaired in patients with COVID-19 and they are not able to prevent the spread of the disease or destroy the infected cells. Few studies have evaluated the effects of COVID-19 vaccines on NK cells, though it has been demonstrated that DNA vaccines and BNT162b2 can affect NK cell response. In the present paper, the effects of SARS-CoV-2 on the NK cells during infection, the effect of vaccination on NK cells, and the NK cell-based therapies were reviewed.
ISSN:1746-0794
DOI:10.2217/fvl-2022-0040