Increase in Cellulose Production by Sulfaguanidine-resistant Mutants Derived from Acetobacter xylinum subsp. sucrofermentans

The relationship between bacterial cellulose production and growth was investigated and the production was found to be associated with growth. Thus, it was expected that enhanced growth would lead to enhanced cellulose production. On the other hand, factors which promote the growth of and cellulose...

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Bibliographic Details
Published inBioscience, biotechnology, and biochemistry Vol. 59; no. 12; pp. 2259 - 2262
Main Authors Ishikawa, Atsushi, Matsuoka, Masanobu, Tsuchida, Takayasu, Yoshinaga, Fumihiro
Format Journal Article
LanguageEnglish
Published Tokyo Taylor & Francis 1995
Japan Society for Bioscience Biotechnology and Agrochemistry
Oxford University Press
Subjects
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Microorganism growth
Induction
Cellulose
Production
Microorganism culture
Bacteria
Mutation
Optimization
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Summary:The relationship between bacterial cellulose production and growth was investigated and the production was found to be associated with growth. Thus, it was expected that enhanced growth would lead to enhanced cellulose production. On the other hand, factors which promote the growth of and cellulose production by Acetohacter xylinum subsp. sucrofermentans BPR2001 were investigated and it was found that addition of p-aminobenzoic acid (PABA) has such effects. Therefore, mutants resistant to sulfaguanidine (SG), which is an analog of PABA, were bred from BPR2001. One of the mutants, BPR3001E, showed increased cell growth and had higher productivity, producing 9.7 g/liter of cellulose from 44 g/liter of fructose. The production is 40% higher than that of BPR2001.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.59.2259