Bile acids in immunity: Bidirectional mediators between the host and the microbiota
Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this...
Saved in:
| Published in | Frontiers in immunology Vol. 13; p. 949033 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Frontiers Media S.A
16.08.2022
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | Host-microbiota interactions are bidirectional. On one hand, ecological pressures exerted by the host shape the composition and function of the microbiota. On the other, resident microbes trigger multiple pathways that influence the immunity of the host. Bile acids participate in both parts of this interplay. As host-derived compounds, they display bacteriostatic properties and affect the survival and growth of the members of the microbial community. As microbiota-modified metabolites, they further influence the microbiota composition and, in parallel, modulate the immunity of the host. Here, we provide a comprehensive overview of the mechanisms behind this unique dialogue and discuss how we can harness bile acids to treat intestinal inflammation. |
|---|---|
| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Francesca Ronchi, University of Bern, Switzerland; Xiaojiao Zheng, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, China This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology Edited by: Simone Becattini, Université de Genève, Switzerland |
| ISSN: | 1664-3224 1664-3224 |
| DOI: | 10.3389/fimmu.2022.949033 |