Catalytic enantioselective bromolactonization of alkenoic acids in the presence of palladium complexes

The catalytic enantioselective bromolactonization of alkenoic acids promoted by chiral palladium complexes has been developed, allowing facile synthesis of the corresponding γ-lactones with excellent enantioselectivity (up to 97% ee). The method reported represents a practical entry for the preparat...

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Bibliographic Details
Published inTetrahedron letters Vol. 53; no. 51; pp. 6984 - 6986
Main Authors Lee, Hyun Joo, Kim, Dae Young
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 19.12.2012
Elsevier
Subjects
Alkenoic acids
Asymmetric catalysis
Bromolactonization
Catalysis
Catalysts
Chemistry
Chemistry, Organic
Chiral palladium catalysts
Derivatives
Palladium
Physical Sciences
Science & Technology
Synthesis
Tetrahedrons
γ-Lactones
Bromolactonization
Chiral palladium catalysts
γ-Lactones
Asymmetric catalysis
Alkenoic acids
ELECTROPHILIC ALPHA-AMINATION
ALPHA,BETA-UNSATURATED KETONES
gamma-Lactones
ASYMMETRIC BROMOLACTONIZATION
BETA-KETO-ESTERS
FLUORINATION
FUMARATE DERIVATIVES
MICHAEL ADDITION
MANNICH-TYPE REACTIONS
FRIEDEL-CRAFTS ALKYLATION
CONJUGATE ADDITION
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Summary:The catalytic enantioselective bromolactonization of alkenoic acids promoted by chiral palladium complexes has been developed, allowing facile synthesis of the corresponding γ-lactones with excellent enantioselectivity (up to 97% ee). The method reported represents a practical entry for the preparation of chiral γ-lactone derivatives.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2012.10.051