ALDH2 polymorphism for the risk of cervical carcinogenesis

• Published in: Human cell : official journal of Human Cell Research Society Vol. 29; no. 2; pp. 91 - 95
• Main Authors: Nunobiki, Osamu, Sano, Daisuke, Akashi, Kyoko, Higashida, Taro, Ogasawara, Toshitada, Akise, Hikari, Izuma, Shinji, Torii, Kiyo, Okamoto, Yoshiaki, Tanaka, Ichiro, Ueda, Masatsugu
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.04.2016
• Subjects: Aldehyde Dehydrogenase, Mitochondrial - genetics; Biomedical and Life Sciences; Cell Biology; Female; Genetic Association Studies; Genetic Predisposition to Disease - genetics; Gynecology; Humans; Life Sciences; Oncology; Papillomaviridae - classification; Polymorphism, Genetic - genetics; Reproductive Medicine; Research Article; Risk; Risk Factors; Stem Cells; Surgery; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - virology; ALDH2; Cervical carcinogenesis; SIL; Polymorphism
• ISSN: 1749-0774; 1749-0774
• DOI: 10.1007/s13577-016-0133-y

To investigate the clinical significance of ALDH2 genetic polymorphisms in cervical carcinogenesis. ALDH2 polymorphisms together with human papillomavirus (HPV) types were examined in a total of 195 cervical smear in exfoliated cervical cell samples using Real-Time polymerase chain reaction (PCR) System. The frequency for the AG+AA genotype was seven in the normal group (70.0 %), 16 in the LSIL group (57.1 %), and 27 in the HSIL group (90.0 %). A significant difference was found between the LSIL and HSIL groups ( P  = 0.0064). Patients with HSIL lesions frequently had high-risk HPV infections and concurrently belonged to the AG+AA group. ALDH2 genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population.