High vascular endothelial growth factor gene expression predicts poor outcome in patients with non-luminal A breast cancer

Breast cancer is the most frequent type of cancer among women worldwide. Vascular endothelial growth factor (VEGF), the key modulator of angiogenesis, has been implicated in breast cancer susceptibility and aggressiveness. VEGF expression was determined in 99 breast cancer tissue samples using rever...

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Bibliographic Details
Published inMolecular and clinical oncology Vol. 3; no. 5; pp. 1103 - 1108
Main Authors SA-NGUANRAKSA, DOONYAPAT, CHUANGSUWANICH, TUENJAI, PONGPRUTTIPAN, TAWATCHAI, O-CHAROENRAT, PORNCHAI
Format Journal Article
LanguageEnglish
Published England D.A. Spandidos 01.09.2015
Spandidos Publications
Spandidos Publications UK Ltd
Subjects
Age
angiogenesis
Breast cancer
Cancer therapies
Care and treatment
Cloning
Epidermal growth factor
Estrogens
Gene expression
Genetic aspects
growth factor
hormone receptor
Hospitals
human epidermal growth factor receptor 2
Medical prognosis
Metastasis
Multivariate analysis
Oncology
Patients
Physiological aspects
Rodents
Surgery
Vascular endothelial growth factor
Womens health
Thailand
growth factor
breast cancer
human epidermal growth factor receptor 2
hormone receptor
angiogenesis
vascular endothelial growth factor
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Summary:Breast cancer is the most frequent type of cancer among women worldwide. Vascular endothelial growth factor (VEGF), the key modulator of angiogenesis, has been implicated in breast cancer susceptibility and aggressiveness. VEGF expression was determined in 99 breast cancer tissue samples using reverse transcription-polymerase chain reaction and the human epidermal growth factor receptor 2 (HER2) status was determined by immunohistochemistry. Subsequently, the associations of VEGF, HER2 and hormone receptor status with clinicopathological data were evaluated. High VEGF expression was found to be significantly correlated with the presence of lymphovascular invasion. In hormone receptor-positive/HER2-positive, HER2-positive and triple-negative breast cancer, high VEGF expression was correlated with the presence of axillary nodal metastasis and lower overall survival rates. Therefore, the assessment of the VEGF status along with the hormone receptor and HER2 status may help identify high-risk patients who may benefit from anti-VEGF treatment.
Bibliography:ObjectType-Article-1
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ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2015.574