Biocompatible bacterial cellulose membrane in dural defect repair of rat

Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molas...

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Published inJournal of materials science. Materials in medicine Vol. 28; no. 3; pp. 37 - 7
Main Authors Lima, Frederico de Melo Tavares de, Pinto, Flávia Cristina Morone, Andrade-da-Costa, Belmira Lara da Silveira, Silva, Jaiurte Gomes Martins da, Campos Júnior, Olávio, Aguiar, José Lamartine de Andrade
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2017
Springer Nature B.V
Subjects
Animals
Bacteria
Bacteria - chemistry
Biocompatibility
Biocompatibility Studies
Biocompatible Materials - chemistry
Biomaterials
Biomedical Engineering and Bioengineering
Biomedical materials
Cellulose
Cellulose - chemistry
Ceramics
Chemistry and Materials Science
Composites
Defects
Dura Mater - drug effects
Dura Mater - injuries
Glass
Immune System
Inflammation
Male
Materials Science
Membranes
Molasses
Natural Materials
Polymer Sciences
Rats
Rats, Wistar
Regenerative Medicine/Tissue Engineering
Repair
Saccharum
Surfaces and Interfaces
Thin Films
Wound Healing
Sugarcane Molas
Bacterial Cellulose Membrane
Dural Substitute
Bacterial Cellulose
Bacterial Cellulose Film
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Summary:Duraplasty is necessary in nearly 30% of all neurological surgeries. Different tissues and materials have been evaluated in dura mater repair or as dural substitutes in neurosurgery. The aim was to evaluate the biocompatibility of the bacterial cellulose (BC) membranes, produced from sugarcane molasses, for dural defect repair in rats. Forty adults males Wistar rats divided into two groups: a control (ePTFE) and an experimental (BC). Bilateral frontoparietal craniectomy was performed, and a dural defect was created. The arachnoid underlying defect was disrupted with a narrow hook. The animals were observed for 120 days. There were no cases of infection, cerebrospinal fluid fistulae, delayed hemorrhages, behavior disturbances, seizures and palsies. The BC membrane showed to have suitable biocompatibility properties, was not induced immune reaction, nor chronic inflammatory response and absence of neurotoxicity signals. Graphical Abstract
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0957-4530
1573-4838
DOI:10.1007/s10856-016-5828-9